Abstract
To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the controls. By a quantitative reverse transcriptase-polymerase chain reaction, the mRNA levels of granulysin were decreased in 30 SSPE patients, and were increased in 7 measles patients, as compared to the 23 controls. These results imply that granulysin might play a role in the host defense against measles virus and possibly be involved in the pathogenesis or pathophysiology of SSPE.
| Original language | English |
|---|---|
| Pages (from-to) | 299-305 |
| Number of pages | 7 |
| Journal | Journal of NeuroVirology |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 1 2005 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology
Cite this
Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays. / Takemoto, Megumi; Kira, Ryutaro; Kusuhara, Koichi; Torisu, Hiroyuki; Sakai, Yasunari; Hara, Toshiro.
In: Journal of NeuroVirology, Vol. 11, No. 3, 01.07.2005, p. 299-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays
AU - Takemoto, Megumi
AU - Kira, Ryutaro
AU - Kusuhara, Koichi
AU - Torisu, Hiroyuki
AU - Sakai, Yasunari
AU - Hara, Toshiro
PY - 2005/7/1
Y1 - 2005/7/1
N2 - To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the controls. By a quantitative reverse transcriptase-polymerase chain reaction, the mRNA levels of granulysin were decreased in 30 SSPE patients, and were increased in 7 measles patients, as compared to the 23 controls. These results imply that granulysin might play a role in the host defense against measles virus and possibly be involved in the pathogenesis or pathophysiology of SSPE.
AB - To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the controls. By a quantitative reverse transcriptase-polymerase chain reaction, the mRNA levels of granulysin were decreased in 30 SSPE patients, and were increased in 7 measles patients, as compared to the 23 controls. These results imply that granulysin might play a role in the host defense against measles virus and possibly be involved in the pathogenesis or pathophysiology of SSPE.
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U2 - 10.1080/13550280590953825
DO - 10.1080/13550280590953825
M3 - Article
VL - 11
SP - 299
EP - 305
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
IS - 3
ER -