Gene Polymorphism-related Individual and Interracial Differences in the Outcomes of Androgen Deprivation Therapy for Prostate Cancer

Naohiro Fujimoto, Masaki Shiota, Ikko Tomisaki, Akinori Minato

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Among patients with prostate cancer, the prognosis after androgen deprivation therapy differs significantly among individuals and among races; however, the reasons underlying these differences are poorly understood. Several single nucleotide polymorphisms in genes associated with prostate cancer progression or castration resistance might serve as the host factor that influences prognosis and, thus, accounts for these individual and racial gaps in treatment outcomes. Accordingly, single nucleotide polymorphisms associated with treatment outcomes could be used as predictive and/or prognostic biomarkers for patient stratification and to identify personalized treatment and follow-up protocols. The present review has summarized the genetic polymorphisms that have been reported to associate with androgen deprivation therapy outcomes among patients with prostate cancer and compared the allele frequencies among different ethnic groups.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalClinical Genitourinary Cancer
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Urology

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