TY - JOUR
T1 - Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
AU - Furue, Masutaka
AU - Tsuji, Gaku
AU - Mitoma, Chikage
AU - Nakahara, Takeshi
AU - Chiba, Takahito
AU - Morino-Koga, Saori
AU - Uchi, Hiroshi
N1 - Funding Information:
This work was supported by a research grant from the Ministry of Health, Labour and Welfare, Japan (H27-Designated Research-017).
Publisher Copyright:
© 2015 Japanese Society for Investigative Dermatology.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
AB - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
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U2 - 10.1016/j.jdermsci.2015.07.011
DO - 10.1016/j.jdermsci.2015.07.011
M3 - Review article
C2 - 26276439
AN - SCOPUS:84949315200
VL - 80
SP - 83
EP - 88
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 2
ER -