Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

Masutaka Furue, Gaku Tsuji, Chikage Mitoma, Takeshi Nakahara, Takahito Chiba, Saori Koga, Uchi Hiroshi

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalJournal of Dermatological Science
Volume80
Issue number2
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Aryl Hydrocarbon Receptors
Gene expression
Skin
Genes
Proteins
Ligands
Aryl Hydrocarbon Receptor Nuclear Translocator
Antioxidants
Coal Tar
Dioxins
Oxidative stress
Transcription
Flavonoids
Tryptophan
Ligation
filaggrin
Oxidative Stress
Transcription Factors
Up-Regulation
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor. / Furue, Masutaka; Tsuji, Gaku; Mitoma, Chikage; Nakahara, Takeshi; Chiba, Takahito; Koga, Saori; Hiroshi, Uchi.

In: Journal of Dermatological Science, Vol. 80, No. 2, 01.11.2015, p. 83-88.

Research output: Contribution to journalReview article

@article{ec83ce8277904e079dd8147f83367ae5,
title = "Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor",
abstract = "Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.",
author = "Masutaka Furue and Gaku Tsuji and Chikage Mitoma and Takeshi Nakahara and Takahito Chiba and Saori Koga and Uchi Hiroshi",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.jdermsci.2015.07.011",
language = "English",
volume = "80",
pages = "83--88",
journal = "Journal of Dermatological Science",
issn = "0923-1811",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor

AU - Furue, Masutaka

AU - Tsuji, Gaku

AU - Mitoma, Chikage

AU - Nakahara, Takeshi

AU - Chiba, Takahito

AU - Koga, Saori

AU - Hiroshi, Uchi

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

AB - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.

UR - http://www.scopus.com/inward/record.url?scp=84949315200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949315200&partnerID=8YFLogxK

U2 - 10.1016/j.jdermsci.2015.07.011

DO - 10.1016/j.jdermsci.2015.07.011

M3 - Review article

C2 - 26276439

AN - SCOPUS:84949315200

VL - 80

SP - 83

EP - 88

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

SN - 0923-1811

IS - 2

ER -