Abstract
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
| Original language | English |
|---|---|
| Pages (from-to) | 83-88 |
| Number of pages | 6 |
| Journal | Journal of Dermatological Science |
| Volume | 80 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Nov 1 2015 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Dermatology
Cite this
Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor. / Furue, Masutaka; Tsuji, Gaku; Mitoma, Chikage; Nakahara, Takeshi; Chiba, Takahito; Koga, Saori; Hiroshi, Uchi.
In: Journal of Dermatological Science, Vol. 80, No. 2, 01.11.2015, p. 83-88.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Gene regulation of filaggrin and other skin barrier proteins via aryl hydrocarbon receptor
AU - Furue, Masutaka
AU - Tsuji, Gaku
AU - Mitoma, Chikage
AU - Nakahara, Takeshi
AU - Chiba, Takahito
AU - Koga, Saori
AU - Hiroshi, Uchi
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
AB - Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to structurally diverse chemicals including dioxins, coal tar, flavonoids and tryptophan photoproducts. Upon ligation, cytoplasmic AHR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator and mediates numerous biological effects by inducing the transcription of various AHR-responsive genes such as epidermal barrier proteins. The activation of AHR usually generates oxidative stress. However, AHR also mediates antioxidant signaling by a plethora of ligands via nuclear factor-erythroid 2-related factor-2. Both oxidative and antioxidant ligands upregulate the expression of the filaggrin gene. We review the role of AHR signaling in the gene regulation of epidermal barrier proteins.
UR - http://www.scopus.com/inward/record.url?scp=84949315200&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949315200&partnerID=8YFLogxK
U2 - 10.1016/j.jdermsci.2015.07.011
DO - 10.1016/j.jdermsci.2015.07.011
M3 - Review article
C2 - 26276439
AN - SCOPUS:84949315200
VL - 80
SP - 83
EP - 88
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 2
ER -