Gene therapy for lung cancer treatment

K. Takayama, Yoichi Nakanishi, N. Hara

Research output: Contribution to journalReview article

Abstract

Gene therapy is a promising strategy for cancer treatment. The strategy is categorized to some fields based on the anti-cancer mechanism. p53 gene therapy and antisense therapy exert the cytotoxic effect on cancer cells by apoptosis induction. In suicide gene therapy, expressed suicide gene product kills the cancer cells in combination with prodrug which metabolite is cytotoxic agent. Oncolytic virus replicates in the tumor selectively and destroys the cancer cells. Immunogene therapy potentiates the antigenicity of cancer cells or activate the immune effector cells. In antiangiogenesis gene therapy, neovascularization is inhibited with antiangiogenic molecule gene such as angiostatin. On the other hand, bone marrow stem cells are protected from high dose anti-cancer agents by the transfer of multi-drug resistant gene.

Original languageEnglish
Pages (from-to)1048-1052
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume58
Issue number5
Publication statusPublished - Jan 1 2000

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Genetic Therapy
Lung Neoplasms
Neoplasms
Therapeutics
Suicide
Angiostatins
Oncolytic Viruses
Hand Bones
Genes
p53 Genes
Cytotoxins
Prodrugs
Bone Marrow Cells
Stem Cells
Apoptosis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Takayama, K., Nakanishi, Y., & Hara, N. (2000). Gene therapy for lung cancer treatment. Nippon rinsho. Japanese journal of clinical medicine, 58(5), 1048-1052.

Gene therapy for lung cancer treatment. / Takayama, K.; Nakanishi, Yoichi; Hara, N.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 58, No. 5, 01.01.2000, p. 1048-1052.

Research output: Contribution to journalReview article

Takayama, K, Nakanishi, Y & Hara, N 2000, 'Gene therapy for lung cancer treatment', Nippon rinsho. Japanese journal of clinical medicine, vol. 58, no. 5, pp. 1048-1052.
Takayama K, Nakanishi Y, Hara N. Gene therapy for lung cancer treatment. Nippon rinsho. Japanese journal of clinical medicine. 2000 Jan 1;58(5):1048-1052.
Takayama, K. ; Nakanishi, Yoichi ; Hara, N. / Gene therapy for lung cancer treatment. In: Nippon rinsho. Japanese journal of clinical medicine. 2000 ; Vol. 58, No. 5. pp. 1048-1052.
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