Generalized melanosis in metastatic malignant melanoma: The possible role of DOPAquinone metabolites

K. Tsukamoto, M. Furue, Y. Sato, O. Takayama, R. Akasu, N. Ohtake, K. Wakamatsu, S. Ito, K. Tamaki, S. Shimada

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Generalized melanosis occurs very rarely as a complication of malignant melanoma, and the pathogenesis of this condition is still unclear. Histological examination of pigmented skin and measurements of the DOPAquinone metabolites 5-S-cysteinyldopa (5-S-CD) and 6-hydroxy-5-methoxyindole-2-carboxylic acid (6H5MI2C) in the patient's serum and urine were carried out. Histological examination revealed basal hyperpigmentation, discrete melanoma cells and melanophages around the blood vessels and an unusual melanin deposition within collagen bundles in the dermis. The levels of 5-S-CD and 6H5MI2C were dramatically increased both in the patient's serum and urine. The deposition of DOPAquinone metabolites secreted by the melanoma cells may contribute to the unusual melanin deposition within collagen bundles in the affected dermis.

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalDermatology
Volume197
Issue number4
DOIs
Publication statusPublished - Dec 1 1998

All Science Journal Classification (ASJC) codes

  • Dermatology

Fingerprint Dive into the research topics of 'Generalized melanosis in metastatic malignant melanoma: The possible role of DOPAquinone metabolites'. Together they form a unique fingerprint.

Cite this