TY - JOUR
T1 - Generation and histomorphometric evaluation of a novel fluvastatin-containing poly(lactic-co-glycolic acid) membrane for guided bone regeneration
AU - Zhang, Haomiao
AU - Moriyama, Yasuko
AU - Ayukawa, Yasunori
AU - Rakhmatia, Yunia Dwi
AU - Tomita, Yoko
AU - Yasunami, Noriyuki
AU - Koyano, Kiyoshi
N1 - Funding Information:
Acknowledgements This study was supported in part by KAKENHI (no. 15H06490) from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2018, The Society of The Nippon Dental University.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/1/25
Y1 - 2019/1/25
N2 - The purpose of this study was to evaluate the effects of a poly(lactic-co-glycolic acid) (PLGA) membrane containing fluvastatin on bone regeneration at bone defects in rat calvaria and tibia for possible use as a guided bone regeneration (GBR) membrane. PLGA and fluvastatin-containing PLGA (PLGA–fluvastatin) membranes were prepared and mechanical properties were evaluated. Standardized bony defects were created in rat calvaria and the right tibia, and covered with a PLGA or PLGA–fluvastatin membrane. Bone regeneration was evaluated using image analysis based on histologic examination. At 4 and 8 weeks after membrane implantation, the PLGA–fluvastatin group displayed enhanced new bone formation around the edge of the defect compared with the PLGA membrane group in the calvarial model. Thick bone regeneration was observed in tibia-defect sites in the PLGA–fluvastatin membrane group. These results suggest that the PLGA-containing fluvastatin membrane prepared in this study may potentially be used as a GBR membrane.
AB - The purpose of this study was to evaluate the effects of a poly(lactic-co-glycolic acid) (PLGA) membrane containing fluvastatin on bone regeneration at bone defects in rat calvaria and tibia for possible use as a guided bone regeneration (GBR) membrane. PLGA and fluvastatin-containing PLGA (PLGA–fluvastatin) membranes were prepared and mechanical properties were evaluated. Standardized bony defects were created in rat calvaria and the right tibia, and covered with a PLGA or PLGA–fluvastatin membrane. Bone regeneration was evaluated using image analysis based on histologic examination. At 4 and 8 weeks after membrane implantation, the PLGA–fluvastatin group displayed enhanced new bone formation around the edge of the defect compared with the PLGA membrane group in the calvarial model. Thick bone regeneration was observed in tibia-defect sites in the PLGA–fluvastatin membrane group. These results suggest that the PLGA-containing fluvastatin membrane prepared in this study may potentially be used as a GBR membrane.
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U2 - 10.1007/s10266-018-0376-z
DO - 10.1007/s10266-018-0376-z
M3 - Article
C2 - 30022371
AN - SCOPUS:85050117795
SN - 1618-1247
VL - 107
SP - 37
EP - 45
JO - Odontology / the Society of the Nippon Dental University
JF - Odontology / the Society of the Nippon Dental University
IS - 1
ER -