Abstract
The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed phenomena that are indicative of the involvement of a self-enhancement and lateral-inhibition (SELI) system. We constructed a mathematical SELI model that not only simulates, but also predicts, experimental data. As predicted by the model, Nodal expression initiates even on the right side. These results indicate that directional flow represents an initial small difference between the left and right sides of the embryo, but is insufficient to determine embryonic situs. Nodal and Lefty are deployed as a SELI system required to amplify this initial bias and convert it into robust asymmetry.
| Original language | English |
|---|---|
| Pages (from-to) | 495-504 |
| Number of pages | 10 |
| Journal | Developmental Cell |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1 2006 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
Cite this
Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System. / Nakamura, Tetsuya; Mine, Naoki; Nakaguchi, Etsushi; Mochizuki, Atsushi; Yamamoto, Masamichi; Yashiro, Kenta; Meno, Chikara; Hamada, Hiroshi.
In: Developmental Cell, Vol. 11, No. 4, 01.10.2006, p. 495-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System
AU - Nakamura, Tetsuya
AU - Mine, Naoki
AU - Nakaguchi, Etsushi
AU - Mochizuki, Atsushi
AU - Yamamoto, Masamichi
AU - Yashiro, Kenta
AU - Meno, Chikara
AU - Hamada, Hiroshi
PY - 2006/10/1
Y1 - 2006/10/1
N2 - The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed phenomena that are indicative of the involvement of a self-enhancement and lateral-inhibition (SELI) system. We constructed a mathematical SELI model that not only simulates, but also predicts, experimental data. As predicted by the model, Nodal expression initiates even on the right side. These results indicate that directional flow represents an initial small difference between the left and right sides of the embryo, but is insufficient to determine embryonic situs. Nodal and Lefty are deployed as a SELI system required to amplify this initial bias and convert it into robust asymmetry.
AB - The bilateral symmetry of the mouse embryo is broken by leftward fluid flow in the node. However, it is unclear how this directional flow is then translated into the robust, left side-specific Nodal gene expression that determines and coordinates left-right situs throughout the embryo. While manipulating Nodal and Lefty gene expression, we have observed phenomena that are indicative of the involvement of a self-enhancement and lateral-inhibition (SELI) system. We constructed a mathematical SELI model that not only simulates, but also predicts, experimental data. As predicted by the model, Nodal expression initiates even on the right side. These results indicate that directional flow represents an initial small difference between the left and right sides of the embryo, but is insufficient to determine embryonic situs. Nodal and Lefty are deployed as a SELI system required to amplify this initial bias and convert it into robust asymmetry.
UR - http://www.scopus.com/inward/record.url?scp=33749042595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749042595&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2006.08.002
DO - 10.1016/j.devcel.2006.08.002
M3 - Article
C2 - 17011489
AN - SCOPUS:33749042595
VL - 11
SP - 495
EP - 504
JO - Developmental Cell
JF - Developmental Cell
SN - 1534-5807
IS - 4
ER -