TY - JOUR
T1 - Genetic Analysis of a Case of Glioblastoma with Oligodendroglial Component Arising During the Progression of Diffuse Astrocytoma
AU - Hata, Nobuhiro
AU - Suzuki, Satoshi O.
AU - Murata, Hideki
AU - Hatae, Ryusuke
AU - Akagi, Yojiro
AU - Sangatsuda, Yuhei
AU - Amano, Toshiyuki
AU - Yoshimoto, Koji
AU - Tahira, Tomoko
AU - Mizoguchi, Masahiro
N1 - Funding Information:
We thank Ms. Fumie Doi and Aki Yoshinaga for technical assistance. This work was funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Grant Number: 23791608.
Publisher Copyright:
© 2014, Arányi Lajos Foundation.
PY - 2015/7/28
Y1 - 2015/7/28
N2 - The most recent definition of glioblastoma with oligodendroglioma component (GBMO) assigned clinical significance to the observation of oligodendroglial foci within glioblastomas. However, the pathological mechanism of its histogenesis has not yet been determined. We report the genetic analysis of a GBMO case that evolved from an astrocyte lineage. A 37-year-old male underwent a third craniotomy for the removal of recurrent lesions of a secondary glioblastoma originating from a previous diffuse astrocytoma. The lesion in the right frontal lobe contained oligodendroglial foci within a glioblastoma background, while the remaining lesions showed only classic glioblastoma histology. Genetic analyses revealed distal 10q loss of heterozygosity (LOH) occurring de novo in the oligodendroglial tissue, as well as 10p, 17p LOH, and isocitrate dehydrogenase-1 gene (IDH1) mutations inherited from the previous lesions. The final recurrent glioblastoma underwent LOH on almost the entire of chromosome 10. Based on these results, the importance of an oligodendroglial component in glioblastomas may be limited.
AB - The most recent definition of glioblastoma with oligodendroglioma component (GBMO) assigned clinical significance to the observation of oligodendroglial foci within glioblastomas. However, the pathological mechanism of its histogenesis has not yet been determined. We report the genetic analysis of a GBMO case that evolved from an astrocyte lineage. A 37-year-old male underwent a third craniotomy for the removal of recurrent lesions of a secondary glioblastoma originating from a previous diffuse astrocytoma. The lesion in the right frontal lobe contained oligodendroglial foci within a glioblastoma background, while the remaining lesions showed only classic glioblastoma histology. Genetic analyses revealed distal 10q loss of heterozygosity (LOH) occurring de novo in the oligodendroglial tissue, as well as 10p, 17p LOH, and isocitrate dehydrogenase-1 gene (IDH1) mutations inherited from the previous lesions. The final recurrent glioblastoma underwent LOH on almost the entire of chromosome 10. Based on these results, the importance of an oligodendroglial component in glioblastomas may be limited.
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U2 - 10.1007/s12253-014-9850-2
DO - 10.1007/s12253-014-9850-2
M3 - Article
C2 - 25354913
AN - SCOPUS:84938054140
SN - 1219-4956
VL - 21
SP - 839
EP - 843
JO - Pathology and Oncology Research
JF - Pathology and Oncology Research
IS - 3
ER -
