Genetic analysis of subacute (de Quervain's) thyroiditis

H. Goto, H. Uno, H. Tamai, K. Kuma, Y. Hayashi, S. Matsubayashi, T. Sasazuki

Research output: Contribution to journalArticle

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Abstract

A weak association between subacute (de Quervain's) thyroiditis and HLA‐DRw8 (relative risk = 2.19, X2= 3.86) was observed. However, the association was not statistically significant if p value was corrected. Since it was confirmed that the association of subacute thyroiditis with HLA‐B35 was primary, and since this association was extremely strong, the two models (dominant and recessive) for the effect of an HLA‐linked gene which has a major effect on the pathogenesis of subacute thyroiditis were tested by the method described by Thomson & Bodmer using the frequency of HLA‐B35 in the patients. The data most fit to the recessive model for the HLA‐linked major gene involved in subacute thyroiditis.

Original languageEnglish
Pages (from-to)110-113
Number of pages4
JournalTissue antigens
Volume26
Issue number2
DOIs
Publication statusPublished - Aug 1985

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Subacute Thyroiditis
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Goto, H., Uno, H., Tamai, H., Kuma, K., Hayashi, Y., Matsubayashi, S., & Sasazuki, T. (1985). Genetic analysis of subacute (de Quervain's) thyroiditis. Tissue antigens, 26(2), 110-113. https://doi.org/10.1111/j.1399-0039.1985.tb00942.x

Genetic analysis of subacute (de Quervain's) thyroiditis. / Goto, H.; Uno, H.; Tamai, H.; Kuma, K.; Hayashi, Y.; Matsubayashi, S.; Sasazuki, T.

In: Tissue antigens, Vol. 26, No. 2, 08.1985, p. 110-113.

Research output: Contribution to journalArticle

Goto, H, Uno, H, Tamai, H, Kuma, K, Hayashi, Y, Matsubayashi, S & Sasazuki, T 1985, 'Genetic analysis of subacute (de Quervain's) thyroiditis', Tissue antigens, vol. 26, no. 2, pp. 110-113. https://doi.org/10.1111/j.1399-0039.1985.tb00942.x
Goto H, Uno H, Tamai H, Kuma K, Hayashi Y, Matsubayashi S et al. Genetic analysis of subacute (de Quervain's) thyroiditis. Tissue antigens. 1985 Aug;26(2):110-113. https://doi.org/10.1111/j.1399-0039.1985.tb00942.x
Goto, H. ; Uno, H. ; Tamai, H. ; Kuma, K. ; Hayashi, Y. ; Matsubayashi, S. ; Sasazuki, T. / Genetic analysis of subacute (de Quervain's) thyroiditis. In: Tissue antigens. 1985 ; Vol. 26, No. 2. pp. 110-113.
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