Genetic analysis of subacute (de Quervain's) thyroiditis

H. Goto; H. Uno; H. Tamai; K. Kuma; Y. Hayashi; S. Matsubayashi; T. Sasazuki

doi:10.1111/j.1399-0039.1985.tb00942.x

Genetic analysis of subacute (de Quervain's) thyroiditis

H. Goto, H. Uno, H. Tamai, K. Kuma, Y. Hayashi, S. Matsubayashi, T. Sasazuki

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A weak association between subacute (de Quervain's) thyroiditis and HLA‐DRw8 (relative risk = 2.19, X²= 3.86) was observed. However, the association was not statistically significant if p value was corrected. Since it was confirmed that the association of subacute thyroiditis with HLA‐B35 was primary, and since this association was extremely strong, the two models (dominant and recessive) for the effect of an HLA‐linked gene which has a major effect on the pathogenesis of subacute thyroiditis were tested by the method described by Thomson & Bodmer using the frequency of HLA‐B35 in the patients. The data most fit to the recessive model for the HLA‐linked major gene involved in subacute thyroiditis.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	Tissue antigens
Volume	26
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.1985.tb00942.x
Publication status	Published - Aug 1985

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.1985.tb00942.x

Cite this

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title = "Genetic analysis of subacute (de Quervain's) thyroiditis",

abstract = "A weak association between subacute (de Quervain's) thyroiditis and HLA‐DRw8 (relative risk = 2.19, X2= 3.86) was observed. However, the association was not statistically significant if p value was corrected. Since it was confirmed that the association of subacute thyroiditis with HLA‐B35 was primary, and since this association was extremely strong, the two models (dominant and recessive) for the effect of an HLA‐linked gene which has a major effect on the pathogenesis of subacute thyroiditis were tested by the method described by Thomson & Bodmer using the frequency of HLA‐B35 in the patients. The data most fit to the recessive model for the HLA‐linked major gene involved in subacute thyroiditis.",

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T1 - Genetic analysis of subacute (de Quervain's) thyroiditis

AU - Goto, H.

AU - Uno, H.

AU - Tamai, H.

AU - Kuma, K.

AU - Hayashi, Y.

AU - Matsubayashi, S.

AU - Sasazuki, T.

PY - 1985/8

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AB - A weak association between subacute (de Quervain's) thyroiditis and HLA‐DRw8 (relative risk = 2.19, X2= 3.86) was observed. However, the association was not statistically significant if p value was corrected. Since it was confirmed that the association of subacute thyroiditis with HLA‐B35 was primary, and since this association was extremely strong, the two models (dominant and recessive) for the effect of an HLA‐linked gene which has a major effect on the pathogenesis of subacute thyroiditis were tested by the method described by Thomson & Bodmer using the frequency of HLA‐B35 in the patients. The data most fit to the recessive model for the HLA‐linked major gene involved in subacute thyroiditis.

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Genetic analysis of subacute (de Quervain's) thyroiditis

Abstract

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