Genetic and immunological differences between Japanese patients with diffuse scleroderma and limited scleroderma

M. Satoh, M. Akizuki, M. Kuwana, T. Mimori, H. Yamagata, S. Yoshida, M. Homma, T. Yamamoto, T. Sasazuki

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Abstract

Objective. To study the association between HLA-DR and scleroderma (SSc), subsets of SSc, and autoantibodies in SSc. Methods. HLA-DR antigens were determined in 45 Japanese patients with SSc. The association between HLA-DR and SSc, subsets of SSc, and autoantibodies was analyzed in 22 patients with SSc excluding mixed connective tissue disease (MCTD)/overlap syndrome (OL). Results. When the 20 patients with MCTD and 3 patients with OL were excluded from the original patient group, a significant increase of HLA-DR2 was observed (59 vs 29% of controls, p < 0.01). The frequency of DR2 increased to 69% in patients with diffuse SSc (p < 0.01). DR1, which was not found in diffuse SSc, was found in 2 of 9 patients with limited SSc. The frequency of DR2 was significantly higher in patients with antitopoisomerase I (10/12, 83%, p < 0.05). In contrast, DR1 was found only in 2 patients with anticentromere antibodies (ACA), and all 5 patients with ACA had no HLA-DR2 (p < 0.01). Conclusion. Our results suggest that different HLA-DR markers may be associated with the production of distinct autoantibodies in diffuse SSc and limited SSc.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalJournal of Rheumatology
Volume21
Issue number1
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Satoh, M., Akizuki, M., Kuwana, M., Mimori, T., Yamagata, H., Yoshida, S., Homma, M., Yamamoto, T., & Sasazuki, T. (1994). Genetic and immunological differences between Japanese patients with diffuse scleroderma and limited scleroderma. Journal of Rheumatology, 21(1), 111-114.