Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse

Mary F. Lyon, Thomas R. King, Yoichi Gondo, John M. Gardner, Yoshimichi Nakatsu, Eva M. Elcher, Murray H. Brilliant

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

Original languageEnglish
Pages (from-to)6968-6972
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number15
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse'. Together they form a unique fingerprint.

Cite this