Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse

Mary F. Lyon, Thomas R. King, Yoichi Gondo, John M. Gardner, Yoshimichi Nakatsu, Eva M. Elcher, Murray H. Brilliant

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.

Original languageEnglish
Pages (from-to)6968-6972
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number15
DOIs
Publication statusPublished - Jan 1 1992

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Molecular Biology
Alleles
Developmental Genes
Chromosomes, Human, Pair 7
DNA Probes
Pigmentation
Reproduction
Genome
Phenotype

All Science Journal Classification (ASJC) codes

  • General

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Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. / Lyon, Mary F.; King, Thomas R.; Gondo, Yoichi; Gardner, John M.; Nakatsu, Yoshimichi; Elcher, Eva M.; Brilliant, Murray H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 15, 01.01.1992, p. 6968-6972.

Research output: Contribution to journalArticle

Lyon, Mary F. ; King, Thomas R. ; Gondo, Yoichi ; Gardner, John M. ; Nakatsu, Yoshimichi ; Elcher, Eva M. ; Brilliant, Murray H. / Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse. In: Proceedings of the National Academy of Sciences of the United States of America. 1992 ; Vol. 89, No. 15. pp. 6968-6972.
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