Genetic architecture of metabolic rate: Environment specific epistasis between mitochondrial and nuclear genes in an insect

Göran Arnqvist, Damian K. Dowling, Paul Eady, Laurene Gay, Tom Tregenza, Midori Tuda, David J. Hosken

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

The extent to which mitochondrial DNA (mtDNA) variation is involved in adaptive evolutionary change is currently being reevaluated. In particular, emerging evidence suggests that mtDNA genes coevolve with the nuclear genes with which they interact to form the energy producing enzyme complexes in the mitochondria. This suggests that intergenomic epistasis between mitochondrial and nuclear genes may affect whole-organism metabolic phenotypes. Here, we use crossed combinations of mitochondrial and nuclear lineages of the seed beetle Callosobruchus maculatus and assay metabolic rate under two different temperature regimes. Metabolic rate was affected by an interaction between the mitochondrial and nuclear lineages and the temperature regime. Sequence data suggests that mitochondrial genetic variation has a role in determining the outcome of this interaction. Our genetic dissection of metabolic rate reveals a high level of complexity, encompassing genetic interactions over two genomes, and genotype × genotype × environment interactions. The evolutionary implications of these results are twofold. First, because metabolic rate is at the root of life histories, our results provide insights into the complexity of life-history evolution in general, and thermal adaptation in particular. Second, our results suggest a mechanism that could contribute to the maintenance of nonneutral mtDNA polymorphism.

Original languageEnglish
Pages (from-to)3354-3363
Number of pages10
JournalEvolution
Volume64
Issue number12
DOIs
Publication statusPublished - Dec 1 2010

Fingerprint

epistasis
Mitochondrial Genes
Mitochondrial DNA
Insects
mitochondrial DNA
insect
insects
gene
Genotype
life history
Callosobruchus maculatus
Temperature
Bruchidae
genes
genotype-environment interaction
Beetles
Dissection
dissection
Seeds
Mitochondria

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Genetic architecture of metabolic rate : Environment specific epistasis between mitochondrial and nuclear genes in an insect. / Arnqvist, Göran; Dowling, Damian K.; Eady, Paul; Gay, Laurene; Tregenza, Tom; Tuda, Midori; Hosken, David J.

In: Evolution, Vol. 64, No. 12, 01.12.2010, p. 3354-3363.

Research output: Contribution to journalArticle

Arnqvist, Göran ; Dowling, Damian K. ; Eady, Paul ; Gay, Laurene ; Tregenza, Tom ; Tuda, Midori ; Hosken, David J. / Genetic architecture of metabolic rate : Environment specific epistasis between mitochondrial and nuclear genes in an insect. In: Evolution. 2010 ; Vol. 64, No. 12. pp. 3354-3363.
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