Genetic background influences P/Q-type Ca2+ channel α1A subunit mRNA expression in olfactory bulb and reproductive ability of N-type Ca2+ channel α1B subunit-deficient mice

Eiki Takahashi, Takeshi Nagasu

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Abstract

The Ca2+ channel α1B subunit is a pore-forming component capable of generating N-type Ca2+ channel activity. Although the N-type Ca2+ channel plays a role in a variety of neuronal functions, α1B-deficient mice did not show apparent behavioral abnormality. In a previous study, we observed a compensatory increase of mRNA expression of the P/Q-type Ca2+ channel α1A subunit gene in olfactory bulb of α1B-deficient mice with a CBA × C57BL/6 background; these mice showed a normal reproductive ability. In this study, we found that the mRNA expression level of the α1A subunit was the same in olfactory bulb of wild, heterozygous, and homozygous α1B-deficient mice with a CBA/JN background, and the homozygous male mice produced no offspring. These results suggest that the genetic background influences α1A subunit mRNA expression and reproductive ability in α1B-deficient mice.

Original languageEnglish
Pages (from-to)287-298
Number of pages12
JournalBiochemical Genetics
Volume43
Issue number5-6
DOIs
Publication statusPublished - Jun 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

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