Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development

Takahisa Furukawa, Kumiko Tamura, Masashi Kawaichi, Tasuku Honjo, Kenichi Kimura, Yoshitaka Kobayakawa, Teiichi Tanimura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Drosophila RBP-Jx is a novel sequence-specific DNA binding protein encompassing the integrase motif which is highly conserved in various organisms. Its gene has been shown to be identical to Suppressor of Hairless which regulates adult peripheral nervous system (PNS) development. To elucidate the precise function of the RBF-Jx protein in adult PNS development, we analyzed transgenic flies that misexpress the RBP-Jx protein. Such studies have shown that UBF-Jx regulates PNS cell fate in at least two steps: commitment to sensory mother cell by lateral inhibition and terminal differentiation into the socket and shaft cells. Taken together with analysis of phenotypes of Suppressor of Hairless mutants, RBP-Jx shows the synergistic activity with neurogenic genes.

Original languageEnglish
Pages (from-to)701-711
Number of pages11
JournalJapanese Journal of Genetics
Volume69
Issue number6
DOIs
Publication statusPublished - Jan 1 1994

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Peripheral Nervous System
Drosophila
Genes
Integrases
DNA-Binding Proteins
Diptera
Proteins
Stem Cells
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development. / Furukawa, Takahisa; Tamura, Kumiko; Kawaichi, Masashi; Honjo, Tasuku; Kimura, Kenichi; Kobayakawa, Yoshitaka; Tanimura, Teiichi.

In: Japanese Journal of Genetics, Vol. 69, No. 6, 01.01.1994, p. 701-711.

Research output: Contribution to journalArticle

Furukawa, Takahisa ; Tamura, Kumiko ; Kawaichi, Masashi ; Honjo, Tasuku ; Kimura, Kenichi ; Kobayakawa, Yoshitaka ; Tanimura, Teiichi. / Genetic characterization of Drosophila RBP-Jx (Suppressor of Hairless) as a neurogenic gene in adult PNS development. In: Japanese Journal of Genetics. 1994 ; Vol. 69, No. 6. pp. 701-711.
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