Genetic control of immune response and disease susceptibility by the HLA-DQ gene

Y. Nishimura, N. Kamikawaji, K. Fujisawa, H. Yoshizumi, M. Yasunami, A. Kimura, Takehiko Sasazuki

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The particular alleles of the HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ-restricted and antigen-specific CD4+ suppressor/inducer T cells, because (1) a statistically significant association and linkage between low immune responsiveness to the natural antigens and the HLA-DQ gene were observed; (2) antigen-specific CD4+ T cells restricted by the DQ molecules encoded for by the HLA-DQ allele associated with low responsiveness were evidence in many low responders; and (3) anti-HLA-DQ mAb restored the immune response to natural antigens, in some low responders. This HLA-DQ-controlled polymorphism of immune response to the natural antigens may account for the association between HLA-DQ alleles and organ-specific autoimmune diseases.

Original languageEnglish
Pages (from-to)459-466
Number of pages8
JournalResearch in Immunology
Volume142
Issue number5-6
DOIs
Publication statusPublished - Jan 1 1991

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HLA-DQ Antigens
Disease Susceptibility
Immune System Diseases
Genes
T-Lymphocytes
CD4 Antigens
Alleles
Antigens
Internal-External Control
Helper-Inducer T-Lymphocytes
Autoimmune Diseases

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Nishimura, Y., Kamikawaji, N., Fujisawa, K., Yoshizumi, H., Yasunami, M., Kimura, A., & Sasazuki, T. (1991). Genetic control of immune response and disease susceptibility by the HLA-DQ gene. Research in Immunology, 142(5-6), 459-466. https://doi.org/10.1016/0923-2494(91)90048-N

Genetic control of immune response and disease susceptibility by the HLA-DQ gene. / Nishimura, Y.; Kamikawaji, N.; Fujisawa, K.; Yoshizumi, H.; Yasunami, M.; Kimura, A.; Sasazuki, Takehiko.

In: Research in Immunology, Vol. 142, No. 5-6, 01.01.1991, p. 459-466.

Research output: Contribution to journalArticle

Nishimura, Y, Kamikawaji, N, Fujisawa, K, Yoshizumi, H, Yasunami, M, Kimura, A & Sasazuki, T 1991, 'Genetic control of immune response and disease susceptibility by the HLA-DQ gene', Research in Immunology, vol. 142, no. 5-6, pp. 459-466. https://doi.org/10.1016/0923-2494(91)90048-N
Nishimura Y, Kamikawaji N, Fujisawa K, Yoshizumi H, Yasunami M, Kimura A et al. Genetic control of immune response and disease susceptibility by the HLA-DQ gene. Research in Immunology. 1991 Jan 1;142(5-6):459-466. https://doi.org/10.1016/0923-2494(91)90048-N
Nishimura, Y. ; Kamikawaji, N. ; Fujisawa, K. ; Yoshizumi, H. ; Yasunami, M. ; Kimura, A. ; Sasazuki, Takehiko. / Genetic control of immune response and disease susceptibility by the HLA-DQ gene. In: Research in Immunology. 1991 ; Vol. 142, No. 5-6. pp. 459-466.
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