Genetic diagnosis of pancreatic cancer

Kazuhiro Mizumoto, Masao Tanaka

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Genetic analysis of pancreatic juice is a promising aid for the accurate and early diagnosis of pancreatic cancer. K-ras mutation is frequently observed in pancreatic cancer; however, it is not specific for carcinoma because pancreatic adenoma and pancreatitis also show this mutation. Overexpression of p53 protein is solely detected in pancreatic juice from pancreatic cancer patients, but the positivity rate differs among various reports. Telomerase activity in pancreatic juice was detected in 20 of 24 (83.3%) pancreatic cancer patients and in only 1 of 23 (4.3%) pancreatic adenoma patients, while none of 23 (0%) pancreatitis patients showed evident telomerase activity. The relative value for telomerase activity was significantly higher in parcreatic cancer than in adenoma and pancreatitis. Centrosome abnormalities are very frequently seen in pancreas cancer tissues and the detection of these abnormalities is expected to be a potent new diagnostic tool for the genetic analysis of pancreatic juice. Genetic analysis of pancreatic juice will improve the sensitivity and specificity of pancreatic cancer diagnosis.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume9
Issue number1
DOIs
Publication statusPublished - May 18 2002

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Pancreatic Juice
Pancreatic Neoplasms
Telomerase
Pancreatitis
Centrosome
Mutation
Early Detection of Cancer
Adenoma
Carcinoma
Sensitivity and Specificity
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology

Cite this

Genetic diagnosis of pancreatic cancer. / Mizumoto, Kazuhiro; Tanaka, Masao.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 9, No. 1, 18.05.2002, p. 39-44.

Research output: Contribution to journalArticle

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