Genetic influences on smoking behavior and nicotine dependence: A review

Kouichi Yoshimasu, Chikako Kiyohara

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Molecular epidemiologic studies suggest genetic factors in the etiology of smoking behavior. Dopamine receptor genes, transporter genes (serotonin and dopamine), and other genes related to metabolism of nicotine are plausible functional candidate genes. Research examining the role of allelic variation in those genes is being actively pursued with respect to nicotine dependence as well as personality characteristics and mental disorders. Some of these genes were reported to be connected with schizophrenia. Although nicotine dependence itself is one of the mental disorders according to the fourth edition of Diagnostic and Statistical Manual of Mental Disorders and the World Health Organization's International Statistical Classification of Diseases and Related Health Problems-10 nomenclature, the high comorbidity between nicotine dependence and other mental disorders such as schizophrenia or affective disorders has been noted. Therefore, the relationship between those mental disorders and tobacco addiction should be cleared up considering the interactive effect of genetic and environmental factors.

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalJournal of epidemiology
Volume13
Issue number4
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Tobacco Use Disorder
Smoking
Mental Disorders
Genes
Schizophrenia
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Personality Disorders
Dopamine Receptors
International Classification of Diseases
Mood Disorders
Nicotine
Terminology
Diagnostic and Statistical Manual of Mental Disorders
Tobacco
Comorbidity
Epidemiologic Studies
Research

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Genetic influences on smoking behavior and nicotine dependence : A review. / Yoshimasu, Kouichi; Kiyohara, Chikako.

In: Journal of epidemiology, Vol. 13, No. 4, 01.01.2003, p. 183-192.

Research output: Contribution to journalReview article

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