Genetic mutual relationship between PTEN and p53 in gastric cancer

Eiji Oki, Eriko Tokunaga, Toshihiko Nakamura, Naoyuki Ueda, Motonori Futatsugi, Kohjiro Mashino, Manabu Yamamoto, Masayuki Watanabe, Masahiko Ikebe, Yoshihiro Kakeji, Hideo Baba, Yoshihiko Maehara

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30 Citations (Scopus)

Abstract

Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalCancer Letters
Volume227
Issue number1
DOIs
Publication statusPublished - Sep 8 2005

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Oki, E., Tokunaga, E., Nakamura, T., Ueda, N., Futatsugi, M., Mashino, K., Yamamoto, M., Watanabe, M., Ikebe, M., Kakeji, Y., Baba, H., & Maehara, Y. (2005). Genetic mutual relationship between PTEN and p53 in gastric cancer. Cancer Letters, 227(1), 33-38. https://doi.org/10.1016/j.canlet.2004.12.006