Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers

N. Shahib, D. Martaadisoebrata, H. Kondo, Y. Zhou, N. Shinkai, C. Nishimura, K. Kiyoko, T. Matsuda, N. Wake, H. D. Kato

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives. To study the causative conception of malignant gestational trophoblastic neoplasms (GTNs), we analyzed malignant GTNs by microsatellite PCR markers. Method. DNAs extracted from 12 malignant GTNs were subjected to PCR for five different chromosomal locations. Result. Of the 7 cases after a complete mole (CM), 5 were derived from androgenesis, but the remaining 2 were from normal fertilization. Of the 5 cases after nonmolar pregnancies, 2 placental site trophoblastic tumors had alleles from both parents. Of the other 3 choriocarcinomas, 1 was from normal fertilization after spontaneous abortion but 2 originated from androgenesis, suggesting that 1 was from a CM prior to the antecedent abortion, transforming after a long interval. Conclusion. By combining the previous cases with these, our analysis of 39 cases demonstrated that trophoblastic neoplasms can arise from at least three different modes of origin (androgenesis, normal fertilization, and parthenogenesis), and antecedent pregnancy is not always identical to the causative conception. Placental site trophoblastic tumors might have different machinery for carcinogenesis because of the predominance of paternal and maternal contributions. In addition, a long dormancy of trophoblasts before malignant transformation, especially for those originating from normal fertilization, was also suggested.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalGynecologic Oncology
Volume81
Issue number2
DOIs
Publication statusPublished - Jan 1 2001

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Trophoblastic Neoplasms
Gestational Trophoblastic Disease
Fertilization
Placental Site Trophoblastic Tumor
Parthenogenesis
Pregnancy
Polymerase Chain Reaction
Choriocarcinoma
Trophoblasts
Spontaneous Abortion
Microsatellite Repeats
Carcinogenesis
Alleles
Mothers
DNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Shahib, N., Martaadisoebrata, D., Kondo, H., Zhou, Y., Shinkai, N., Nishimura, C., ... Kato, H. D. (2001). Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers. Gynecologic Oncology, 81(2), 247-253. https://doi.org/10.1006/gyno.2001.6145

Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers. / Shahib, N.; Martaadisoebrata, D.; Kondo, H.; Zhou, Y.; Shinkai, N.; Nishimura, C.; Kiyoko, K.; Matsuda, T.; Wake, N.; Kato, H. D.

In: Gynecologic Oncology, Vol. 81, No. 2, 01.01.2001, p. 247-253.

Research output: Contribution to journalArticle

Shahib, N, Martaadisoebrata, D, Kondo, H, Zhou, Y, Shinkai, N, Nishimura, C, Kiyoko, K, Matsuda, T, Wake, N & Kato, HD 2001, 'Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers', Gynecologic Oncology, vol. 81, no. 2, pp. 247-253. https://doi.org/10.1006/gyno.2001.6145
Shahib N, Martaadisoebrata D, Kondo H, Zhou Y, Shinkai N, Nishimura C et al. Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers. Gynecologic Oncology. 2001 Jan 1;81(2):247-253. https://doi.org/10.1006/gyno.2001.6145
Shahib, N. ; Martaadisoebrata, D. ; Kondo, H. ; Zhou, Y. ; Shinkai, N. ; Nishimura, C. ; Kiyoko, K. ; Matsuda, T. ; Wake, N. ; Kato, H. D. / Genetic origin of malignant trophoblastic neoplasms analyzed by sequence tag site polymorphic markers. In: Gynecologic Oncology. 2001 ; Vol. 81, No. 2. pp. 247-253.
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