Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer

Kenji Shibuta, Tsuyoshi Eto, Akemi Kataoka, Hiroshi Inoue, Hiroaki Ueo, Tomokazu Suzuki, Graham F. Barnard, Masaki Mori

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

OBJECTIVE: N-Acetylation polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there remains a controversy and no consensus concerning whether there is a true association between esophageal cancer and N-acetylation polymorphism. METHODS: To analyze the distribution of N-acetyltransferase 2 polymorphism in Japanese patients with esophageal squamous cell cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism was used. RESULTS: Based on an analysis of 71 Japanese patients with esophageal squamous cell cancer and 329 healthy control subjects, the distribution of the slow acetylator phenotype was significantly higher in esophageal cancer patients than in the controls (19.7% and 9.4%, respectively, p = 0.040). The odds ratio of esophageal cancer for the slow phenotype was 2.55 (95% CI = 1.15-5.65, p = 0.023) compared with the rapid type. Furthermore, a significant difference between the distribution of acetylator phenotype and the incidence of lymph node metastasis and lymphatic involvement was found based on the clinicopathological features of these cancers. Esophageal cancer patients with a higher smoking exposure history tended to have the rapid acetylator phenotype. CONCLUSION: These results suggest that N-acetylation polymorphism may be implicated as a genetic trait affecting an individual's susceptibility and biological behavior of esophageal squamous cell cancer.

Original languageEnglish
Pages (from-to)3419-3424
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume96
Issue number12
DOIs
Publication statusPublished - Dec 1 2001

Fingerprint

Acetyltransferases
Genetic Polymorphisms
Esophageal Neoplasms
Squamous Cell Neoplasms
Acetylation
Phenotype
Lymphatic Metastasis
Restriction Fragment Length Polymorphisms
Neoplasms
Consensus
Healthy Volunteers
Lymph Nodes
Smoking
History
Odds Ratio
Polymerase Chain Reaction
Incidence

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer. / Shibuta, Kenji; Eto, Tsuyoshi; Kataoka, Akemi; Inoue, Hiroshi; Ueo, Hiroaki; Suzuki, Tomokazu; Barnard, Graham F.; Mori, Masaki.

In: American Journal of Gastroenterology, Vol. 96, No. 12, 01.12.2001, p. 3419-3424.

Research output: Contribution to journalArticle

Shibuta, K, Eto, T, Kataoka, A, Inoue, H, Ueo, H, Suzuki, T, Barnard, GF & Mori, M 2001, 'Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer', American Journal of Gastroenterology, vol. 96, no. 12, pp. 3419-3424. https://doi.org/10.1016/S0002-9270(01)03838-2
Shibuta, Kenji ; Eto, Tsuyoshi ; Kataoka, Akemi ; Inoue, Hiroshi ; Ueo, Hiroaki ; Suzuki, Tomokazu ; Barnard, Graham F. ; Mori, Masaki. / Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer. In: American Journal of Gastroenterology. 2001 ; Vol. 96, No. 12. pp. 3419-3424.
@article{1ff6eb727e214775a289c05e17f03a4f,
title = "Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer",
abstract = "OBJECTIVE: N-Acetylation polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there remains a controversy and no consensus concerning whether there is a true association between esophageal cancer and N-acetylation polymorphism. METHODS: To analyze the distribution of N-acetyltransferase 2 polymorphism in Japanese patients with esophageal squamous cell cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism was used. RESULTS: Based on an analysis of 71 Japanese patients with esophageal squamous cell cancer and 329 healthy control subjects, the distribution of the slow acetylator phenotype was significantly higher in esophageal cancer patients than in the controls (19.7{\%} and 9.4{\%}, respectively, p = 0.040). The odds ratio of esophageal cancer for the slow phenotype was 2.55 (95{\%} CI = 1.15-5.65, p = 0.023) compared with the rapid type. Furthermore, a significant difference between the distribution of acetylator phenotype and the incidence of lymph node metastasis and lymphatic involvement was found based on the clinicopathological features of these cancers. Esophageal cancer patients with a higher smoking exposure history tended to have the rapid acetylator phenotype. CONCLUSION: These results suggest that N-acetylation polymorphism may be implicated as a genetic trait affecting an individual's susceptibility and biological behavior of esophageal squamous cell cancer.",
author = "Kenji Shibuta and Tsuyoshi Eto and Akemi Kataoka and Hiroshi Inoue and Hiroaki Ueo and Tomokazu Suzuki and Barnard, {Graham F.} and Masaki Mori",
year = "2001",
month = "12",
day = "1",
doi = "10.1016/S0002-9270(01)03838-2",
language = "English",
volume = "96",
pages = "3419--3424",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer

AU - Shibuta, Kenji

AU - Eto, Tsuyoshi

AU - Kataoka, Akemi

AU - Inoue, Hiroshi

AU - Ueo, Hiroaki

AU - Suzuki, Tomokazu

AU - Barnard, Graham F.

AU - Mori, Masaki

PY - 2001/12/1

Y1 - 2001/12/1

N2 - OBJECTIVE: N-Acetylation polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there remains a controversy and no consensus concerning whether there is a true association between esophageal cancer and N-acetylation polymorphism. METHODS: To analyze the distribution of N-acetyltransferase 2 polymorphism in Japanese patients with esophageal squamous cell cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism was used. RESULTS: Based on an analysis of 71 Japanese patients with esophageal squamous cell cancer and 329 healthy control subjects, the distribution of the slow acetylator phenotype was significantly higher in esophageal cancer patients than in the controls (19.7% and 9.4%, respectively, p = 0.040). The odds ratio of esophageal cancer for the slow phenotype was 2.55 (95% CI = 1.15-5.65, p = 0.023) compared with the rapid type. Furthermore, a significant difference between the distribution of acetylator phenotype and the incidence of lymph node metastasis and lymphatic involvement was found based on the clinicopathological features of these cancers. Esophageal cancer patients with a higher smoking exposure history tended to have the rapid acetylator phenotype. CONCLUSION: These results suggest that N-acetylation polymorphism may be implicated as a genetic trait affecting an individual's susceptibility and biological behavior of esophageal squamous cell cancer.

AB - OBJECTIVE: N-Acetylation polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there remains a controversy and no consensus concerning whether there is a true association between esophageal cancer and N-acetylation polymorphism. METHODS: To analyze the distribution of N-acetyltransferase 2 polymorphism in Japanese patients with esophageal squamous cell cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism was used. RESULTS: Based on an analysis of 71 Japanese patients with esophageal squamous cell cancer and 329 healthy control subjects, the distribution of the slow acetylator phenotype was significantly higher in esophageal cancer patients than in the controls (19.7% and 9.4%, respectively, p = 0.040). The odds ratio of esophageal cancer for the slow phenotype was 2.55 (95% CI = 1.15-5.65, p = 0.023) compared with the rapid type. Furthermore, a significant difference between the distribution of acetylator phenotype and the incidence of lymph node metastasis and lymphatic involvement was found based on the clinicopathological features of these cancers. Esophageal cancer patients with a higher smoking exposure history tended to have the rapid acetylator phenotype. CONCLUSION: These results suggest that N-acetylation polymorphism may be implicated as a genetic trait affecting an individual's susceptibility and biological behavior of esophageal squamous cell cancer.

UR - http://www.scopus.com/inward/record.url?scp=0035666794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035666794&partnerID=8YFLogxK

U2 - 10.1016/S0002-9270(01)03838-2

DO - 10.1016/S0002-9270(01)03838-2

M3 - Article

C2 - 11774959

AN - SCOPUS:0035666794

VL - 96

SP - 3419

EP - 3424

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 12

ER -