Genetic structure of the dopamine receptor D4 gene (DRD4) and lack of association with schizophrenia in Japanese patients

Hiroshi Mitsuyasu, Hiroaki Kawasaki, Hideaki Ninomiya, Naoko Kinukawa, Takeharu Yamanaka, Tomoko Tahira, Vincent P. Stanton, Gregory M. Springett, Kenshi Hayashi, Nobutada Tashiro, Shigenobu Kanba

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Abstract

In order to investigate the contribution of genetic variation in the human dopamine receptor D4 gene (DRD4) to the risk of developing schizophrenia, we carried out a genetic analysis of 27 polymorphisms in 216 schizophrenic patients and 243 healthy controls from the Kyushu region of Japan. Twenty-two single nucleotide polymorphisms (SNPs) and five insertion/deletion polymorphisms were analyzed in this study, including four novel SNPs and a novel mononucleotide repeat. Linkage disequilibrium (LD) and haplotype analyses reveal weak LD across the DRD4 gene. In univariate analysis female individuals with allele -521C had a higher risk for schizophrenia. However, this finding was not significant after correction for multiple hypothesis testing. No other polymorphisms or haplotypes differed between schizophrenic patients and controls. Likewise, multivariate analyses did not reveal any statistically significant associations.

Original languageEnglish
Pages (from-to)763-775
Number of pages13
JournalJournal of Psychiatric Research
Volume41
Issue number9
DOIs
Publication statusPublished - Nov 1 2007

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All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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