Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women

Sergio Báez, Yasuo Tsuchiya, Alfonso Calvo, Martha Pruyas, Kazutoshi Nakamura, Chikako Kiyohara, Mari Oyama, Masaharu Yamamoto

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

AIM: To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC). METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffin block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman® SNP Genotyping Assays or Custom Taqman® SNP Genotyping Assays. RESULTS: The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR: 0.14, 95% CI: 0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR: 5.04, 95% CI: 1.43-17.8). CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women.

Original languageEnglish
Pages (from-to)372-378
Number of pages7
JournalWorld Journal of Gastroenterology
Volume16
Issue number3
DOIs
Publication statusPublished - Jan 21 2010

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Gallbladder Neoplasms
Capsaicin
Gallstones
Cholesterol Ester Transfer Proteins
Apolipoproteins B
Single Nucleotide Polymorphism
Genotype
Capsicum
Paraffin
DNA

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women. / Báez, Sergio; Tsuchiya, Yasuo; Calvo, Alfonso; Pruyas, Martha; Nakamura, Kazutoshi; Kiyohara, Chikako; Oyama, Mari; Yamamoto, Masaharu.

In: World Journal of Gastroenterology, Vol. 16, No. 3, 21.01.2010, p. 372-378.

Research output: Contribution to journalArticle

Báez, Sergio ; Tsuchiya, Yasuo ; Calvo, Alfonso ; Pruyas, Martha ; Nakamura, Kazutoshi ; Kiyohara, Chikako ; Oyama, Mari ; Yamamoto, Masaharu. / Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women. In: World Journal of Gastroenterology. 2010 ; Vol. 16, No. 3. pp. 372-378.
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N2 - AIM: To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC). METHODS: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffin block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman® SNP Genotyping Assays or Custom Taqman® SNP Genotyping Assays. RESULTS: The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR: 0.14, 95% CI: 0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR: 5.04, 95% CI: 1.43-17.8). CONCLUSION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women.

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