Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the prometer activity of the long terminal repeat

Y. Tomioka, K. Ochiai, K. Ohashi, E. Ono, T. Toyoda, T. Kimura, T. Umemura

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A). We determined the complete nucleotide sequence of the virus genome. The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes. The coding sequences were well conserved with those of replication-competent viruses, but the 3′ noncoding regions including LTR were most related to those of replication-defective sarcoma viruses. The U3 region of the LTR had a few deletions and several point mutations compared to that of other ALVs. The promoter activities of the LTRs of glioma-inducing ALV and ALV-A standard strain, RAV-1, were equivalent in chick embryo fibroblasts (CEF), while that of glioma-inclucing ALV was significantly lower than that of RAV-1 in human astrocytic cells. These subtle differences of the promoter activity of the LTR may be related to the induction of glial neoplasm.

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalJournal of General Virology
Volume85
Issue number3
DOIs
Publication statusPublished - Mar 1 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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