Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type

Yasuhiro Nakashima, Hiroyuki Tagawa, Ritsuro Suzuki, Sivasundaram Karnan, Kennosuke Karube, Koichi Ohshima, Koichiro Muta, Hajime Nawata, Yasuo Morishima, Shigeo Nakamura, Masao Seto

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array-based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1. In particular, gain of 1q23.1-q24.2 (P = 0.041) and 1q31.3-q44 (P = 0.003-0.047), and loss of 7p15.1-p22.3 (P = 0.012-0.041) and 17p 13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p 16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalGenes Chromosomes and Cancer
Volume44
Issue number3
DOIs
Publication statusPublished - Nov 1 2005

Fingerprint

Large Granular Lymphocytic Leukemia
Natural Killer T-Cells
Comparative Genomic Hybridization
T-Cell Lymphoma
Nose
Natural Killer Cells
Lymphoma
Leukemia
Genome

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

Cite this

Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia : Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type. / Nakashima, Yasuhiro; Tagawa, Hiroyuki; Suzuki, Ritsuro; Karnan, Sivasundaram; Karube, Kennosuke; Ohshima, Koichi; Muta, Koichiro; Nawata, Hajime; Morishima, Yasuo; Nakamura, Shigeo; Seto, Masao.

In: Genes Chromosomes and Cancer, Vol. 44, No. 3, 01.11.2005, p. 247-255.

Research output: Contribution to journalArticle

Nakashima, Yasuhiro ; Tagawa, Hiroyuki ; Suzuki, Ritsuro ; Karnan, Sivasundaram ; Karube, Kennosuke ; Ohshima, Koichi ; Muta, Koichiro ; Nawata, Hajime ; Morishima, Yasuo ; Nakamura, Shigeo ; Seto, Masao. / Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia : Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type. In: Genes Chromosomes and Cancer. 2005 ; Vol. 44, No. 3. pp. 247-255.
@article{75febd961fc846ba81b6b19c5724292b,
title = "Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type",
abstract = "Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array-based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1. In particular, gain of 1q23.1-q24.2 (P = 0.041) and 1q31.3-q44 (P = 0.003-0.047), and loss of 7p15.1-p22.3 (P = 0.012-0.041) and 17p 13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p 16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.",
author = "Yasuhiro Nakashima and Hiroyuki Tagawa and Ritsuro Suzuki and Sivasundaram Karnan and Kennosuke Karube and Koichi Ohshima and Koichiro Muta and Hajime Nawata and Yasuo Morishima and Shigeo Nakamura and Masao Seto",
year = "2005",
month = "11",
day = "1",
doi = "10.1002/gcc.20245",
language = "English",
volume = "44",
pages = "247--255",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia

T2 - Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type

AU - Nakashima, Yasuhiro

AU - Tagawa, Hiroyuki

AU - Suzuki, Ritsuro

AU - Karnan, Sivasundaram

AU - Karube, Kennosuke

AU - Ohshima, Koichi

AU - Muta, Koichiro

AU - Nawata, Hajime

AU - Morishima, Yasuo

AU - Nakamura, Shigeo

AU - Seto, Masao

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array-based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1. In particular, gain of 1q23.1-q24.2 (P = 0.041) and 1q31.3-q44 (P = 0.003-0.047), and loss of 7p15.1-p22.3 (P = 0.012-0.041) and 17p 13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p 16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.

AB - Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array-based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1. In particular, gain of 1q23.1-q24.2 (P = 0.041) and 1q31.3-q44 (P = 0.003-0.047), and loss of 7p15.1-p22.3 (P = 0.012-0.041) and 17p 13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p 16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias.

UR - http://www.scopus.com/inward/record.url?scp=25844434275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844434275&partnerID=8YFLogxK

U2 - 10.1002/gcc.20245

DO - 10.1002/gcc.20245

M3 - Article

C2 - 16049916

AN - SCOPUS:25844434275

VL - 44

SP - 247

EP - 255

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 3

ER -