Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Tomomitsu Hirota; Atsushi Takahashi; Michiaki Kubo; Tatsuhiko Tsunoda; Kaori Tomita; Masafumi Sakashita; Takechiyo Yamada; Shigeharu Fujieda; Shota Tanaka; Satoru Doi; Akihiko Miyatake; Tadao Enomoto; Chiharu Nishiyama; Nobuhiro Nakano; Keiko Maeda; Ko Okumura; Hideoki Ogawa; Shigaku Ikeda; Emiko Noguchi; Tohru Sakamoto; Nobuyuki Hizawa; Koji Ebe; Hidehisa Saeki; Takashi Sasaki; Tamotsu Ebihara; Masayuki Amagai; Satoshi Takeuchi; Masutaka Furue; Yusuke Nakamura; Mayumi Tamari

doi:10.1038/ng.2438

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Masafumi Sakashita, Takechiyo Yamada, Shigeharu Fujieda, Shota Tanaka, Satoru Doi, Akihiko Miyatake, Tadao Enomoto, Chiharu Nishiyama, Nobuhiro Nakano, Keiko Maeda, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, Emiko Noguchi, Tohru SakamotoNobuyuki Hizawa, Koji Ebe, Hidehisa Saeki, Takashi Sasaki, Tamotsu Ebihara, Masayuki Amagai, Satoshi Takeuchi, Masutaka Furue, Yusuke Nakamura, Mayumi Tamari

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Abstract

Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10^-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10^-20), OR10A3-NLRP10 (P = 1.54 × 10^-22), GLB1 (P = 2.77 × 10^-16), CCDC80 (P = 1.56 × 10^-19), CARD11 (P = 7.83 × 10^-9), ZNF365 (P = 5.85 × 10^-20) and CYP24A1-PFDN4 (P = 1.65 × 10^-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.

Original language	English
Pages (from-to)	1222-1226
Number of pages	5
Journal	Nature genetics
Volume	44
Issue number	11
DOIs	https://doi.org/10.1038/ng.2438
Publication status	Published - Nov 2012

All Science Journal Classification (ASJC) codes

Genetics

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10.1038/ng.2438

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Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Tanaka, S., Doi, S., Miyatake, A., Enomoto, T., Nishiyama, C., Nakano, N., Maeda, K., Okumura, K., Ogawa, H., Ikeda, S., Noguchi, E., ... Tamari, M. (2012). Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nature genetics, 44(11), 1222-1226. https://doi.org/10.1038/ng.2438

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. / Hirota, Tomomitsu; Takahashi, Atsushi; Kubo, Michiaki; Tsunoda, Tatsuhiko; Tomita, Kaori; Sakashita, Masafumi; Yamada, Takechiyo; Fujieda, Shigeharu; Tanaka, Shota; Doi, Satoru; Miyatake, Akihiko; Enomoto, Tadao; Nishiyama, Chiharu; Nakano, Nobuhiro; Maeda, Keiko; Okumura, Ko; Ogawa, Hideoki; Ikeda, Shigaku; Noguchi, Emiko; Sakamoto, Tohru; Hizawa, Nobuyuki; Ebe, Koji; Saeki, Hidehisa; Sasaki, Takashi; Ebihara, Tamotsu; Amagai, Masayuki; Takeuchi, Satoshi; Furue, Masutaka; Nakamura, Yusuke; Tamari, Mayumi.

In: Nature genetics, Vol. 44, No. 11, 11.2012, p. 1222-1226.

Research output: Contribution to journal › Article › peer-review

Hirota, T, Takahashi, A, Kubo, M, Tsunoda, T, Tomita, K, Sakashita, M, Yamada, T, Fujieda, S, Tanaka, S, Doi, S, Miyatake, A, Enomoto, T, Nishiyama, C, Nakano, N, Maeda, K, Okumura, K, Ogawa, H, Ikeda, S, Noguchi, E, Sakamoto, T, Hizawa, N, Ebe, K, Saeki, H, Sasaki, T, Ebihara, T, Amagai, M, Takeuchi, S, Furue, M, Nakamura, Y & Tamari, M 2012, 'Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population', Nature genetics, vol. 44, no. 11, pp. 1222-1226. https://doi.org/10.1038/ng.2438

Hirota, Tomomitsu ; Takahashi, Atsushi ; Kubo, Michiaki ; Tsunoda, Tatsuhiko ; Tomita, Kaori ; Sakashita, Masafumi ; Yamada, Takechiyo ; Fujieda, Shigeharu ; Tanaka, Shota ; Doi, Satoru ; Miyatake, Akihiko ; Enomoto, Tadao ; Nishiyama, Chiharu ; Nakano, Nobuhiro ; Maeda, Keiko ; Okumura, Ko ; Ogawa, Hideoki ; Ikeda, Shigaku ; Noguchi, Emiko ; Sakamoto, Tohru ; Hizawa, Nobuyuki ; Ebe, Koji ; Saeki, Hidehisa ; Sasaki, Takashi ; Ebihara, Tamotsu ; Amagai, Masayuki ; Takeuchi, Satoshi ; Furue, Masutaka ; Nakamura, Yusuke ; Tamari, Mayumi. / Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. In: Nature genetics. 2012 ; Vol. 44, No. 11. pp. 1222-1226.

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abstract = "Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P combined = 8.36 × 10-18), the major histocompatibility complex (MHC) region (P = 8.38 × 10-20), OR10A3-NLRP10 (P = 1.54 × 10-22), GLB1 (P = 2.77 × 10-16), CCDC80 (P = 1.56 × 10-19), CARD11 (P = 7.83 × 10-9), ZNF365 (P = 5.85 × 10-20) and CYP24A1-PFDN4 (P = 1.65 × 10-8). We also replicated the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.",

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AU - Yamada, Takechiyo

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AU - Sakamoto, Tohru

AU - Hizawa, Nobuyuki

AU - Ebe, Koji

AU - Saeki, Hidehisa

AU - Sasaki, Takashi

AU - Ebihara, Tamotsu

AU - Amagai, Masayuki

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AU - Furue, Masutaka

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AU - Tamari, Mayumi

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