Abstract
Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role. This Review provides a comprehensive overview of the mechanisms that modulate genomic imprinting and the roles this epigenetic process plays across mammalian physiology.
| Original language | English |
|---|---|
| Pages (from-to) | 952-965 |
| Number of pages | 14 |
| Journal | Cell |
| Volume | 176 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Feb 21 2019 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Genomic Imprinting and Physiological Processes in Mammals. / the Erice Imprinting Group.
In: Cell, Vol. 176, No. 5, 21.02.2019, p. 952-965.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Genomic Imprinting and Physiological Processes in Mammals
AU - the Erice Imprinting Group
AU - Tucci, Valter
AU - Isles, Anthony R.
AU - Kelsey, Gavin
AU - Ferguson-Smith, Anne C.
AU - Bartolomei, Marisa S.
AU - Benvenisty, Nissim
AU - Bourc'his, Déborah
AU - Charalambous, Marika
AU - Dulac, Catherine
AU - Feil, Robert
AU - Glaser, Juliane
AU - Huelsmann, Lisa
AU - John, Rosalind M.
AU - McNamara, Gráinne I.
AU - Moorwood, Kim
AU - Muscatelli, Francoise
AU - Sasaki, Hiroyuki
AU - Strassmann, Beverly I.
AU - Vincenz, Claudius
AU - Wilkins, Jon
PY - 2019/2/21
Y1 - 2019/2/21
N2 - Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role. This Review provides a comprehensive overview of the mechanisms that modulate genomic imprinting and the roles this epigenetic process plays across mammalian physiology.
AB - Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role. This Review provides a comprehensive overview of the mechanisms that modulate genomic imprinting and the roles this epigenetic process plays across mammalian physiology.
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U2 - 10.1016/j.cell.2019.01.043
DO - 10.1016/j.cell.2019.01.043
M3 - Review article
VL - 176
SP - 952
EP - 965
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -