Genomic Imprinting and Physiological Processes in Mammals

the Erice Imprinting Group

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role. This Review provides a comprehensive overview of the mechanisms that modulate genomic imprinting and the roles this epigenetic process plays across mammalian physiology.

Original languageEnglish
Pages (from-to)952-965
Number of pages14
JournalCell
Volume176
Issue number5
DOIs
Publication statusPublished - Feb 21 2019

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Physiological Phenomena
Genomic Imprinting
Mammals
Physiology
Genes
Chromosomes
Epigenomics
Brain
Alleles
Genetic Epigenesis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Genomic Imprinting and Physiological Processes in Mammals. / the Erice Imprinting Group.

In: Cell, Vol. 176, No. 5, 21.02.2019, p. 952-965.

Research output: Contribution to journalReview article

the Erice Imprinting Group 2019, 'Genomic Imprinting and Physiological Processes in Mammals', Cell, vol. 176, no. 5, pp. 952-965. https://doi.org/10.1016/j.cell.2019.01.043
the Erice Imprinting Group. / Genomic Imprinting and Physiological Processes in Mammals. In: Cell. 2019 ; Vol. 176, No. 5. pp. 952-965.
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AU - Bartolomei, Marisa S.

AU - Benvenisty, Nissim

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