Genomic imprinting in mammals: Its life cycle, molecular mechanisms and reprogramming

Yufeng Li, Hiroyuki Sasaki

    Research output: Contribution to journalReview articlepeer-review

    82 Citations (Scopus)

    Abstract

    Genomic imprinting, an epigenetic gene-marking phenomenon that occurs in the germline, leads to parental-origin-specific expression of a small subset of genes in mammals. Imprinting has a great impact on normal mammalian development, fetal growth, metabolism and adult behavior. The epigenetic imprints regarding the parental origin are established during male and female gametogenesis, passed to the zygote through fertilization, maintained throughout development and adult life, and erased in primordial germ cells before the new imprints are set. In this review, we focus on the recent discoveries on the mechanisms involved in the reprogramming and maintenance of the imprints. We also discuss the epigenetic changes that occur at imprinted loci in induced pluripotent stem cells.

    Original languageEnglish
    Pages (from-to)466-473
    Number of pages8
    JournalCell Research
    Volume21
    Issue number3
    DOIs
    Publication statusPublished - Mar 2011

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Cell Biology

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