TY - JOUR
T1 - Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms
AU - Li, Yongxin
AU - Omori, Akihito
AU - Flores, Rachel L.
AU - Satterfield, Sheri
AU - Nguyen, Christine
AU - Ota, Tatsuya
AU - Tsurugaya, Toko
AU - Ikuta, Tetsuro
AU - Ikeo, Kazuho
AU - Kikuchi, Mani
AU - Leong, Jason C.K.
AU - Reich, Adrian
AU - Hao, Meng
AU - Wan, Wenting
AU - Dong, Yang
AU - Ren, Yaondong
AU - Zhang, Si
AU - Zeng, Tao
AU - Uesaka, Masahiro
AU - Uchida, Yui
AU - Li, Xueyan
AU - Shibata, Tomoko F.
AU - Bino, Takahiro
AU - Ogawa, Kota
AU - Shigenobu, Shuji
AU - Kondo, Mariko
AU - Wang, Fayou
AU - Chen, Luonan
AU - Wessel, Gary
AU - Saiga, Hidetoshi
AU - Cameron, R. Andrew
AU - Livingston, Brian
AU - Bradham, Cynthia
AU - Wang, Wen
AU - Irie, Naoki
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 31561143016; No. 31621062 and Strategic International Collaborative Research Program (SICORP) of JST. We thank Flore Castellan for help drawing animals and embryos. GMW gratefully acknowledges support in part from NIH 9RO1GM125071.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, and proteomes of diverse echinoderms including the green sea urchin (L. variegatus), a sea cucumber (A. japonicus), and with particular emphasis on a sister group of the earliest-diverged echinoderms, the feather star (A. japonica). We learned that the last common ancestor of echinoderms retained a well-organized Hox cluster reminiscent of the hemichordate, and had gene sets involved in endoskeleton development. Further, unlike in other animal groups, the most conserved developmental stages were not at the body plan establishing phase, and genes normally involved in bilaterality appear to function in pentameric axis development. These results enhance our understanding of the divergence of protostomes and deuterostomes almost 500 Mya.
AB - Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, and proteomes of diverse echinoderms including the green sea urchin (L. variegatus), a sea cucumber (A. japonicus), and with particular emphasis on a sister group of the earliest-diverged echinoderms, the feather star (A. japonica). We learned that the last common ancestor of echinoderms retained a well-organized Hox cluster reminiscent of the hemichordate, and had gene sets involved in endoskeleton development. Further, unlike in other animal groups, the most conserved developmental stages were not at the body plan establishing phase, and genes normally involved in bilaterality appear to function in pentameric axis development. These results enhance our understanding of the divergence of protostomes and deuterostomes almost 500 Mya.
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U2 - 10.1038/s42003-020-1091-1
DO - 10.1038/s42003-020-1091-1
M3 - Article
C2 - 32651448
AN - SCOPUS:85087761381
SN - 2399-3642
VL - 3
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 371
ER -