Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor

Hitoshi Hashimoto, Akiko Nishino, Norihito Shintani, Nami Hagihara, Neal G. Copeland, Nancy A. Jenkins, Kyohei Yamamoto, Toshio Matsuda, Takeshi Ishihara, Shigekazu Nagata, Akemichi Baba

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22 Citations (Scopus)

Abstract

The gene encoding the mouse vasoactive intestinal polypeptide type 1 (VPAC1) receptor was cloned, and its structural organization was determined. The gene (Vipr1) is more than 16 kh in length and is divided into 13 exons. The 5'-flanking region is highly GC-rich and lacks an apparent TATA box, but contains a CCAAT box, three potential Sp1-binding sites, and two potential AP-2-binding sites. Promoter analysis of the 5'-flanking region of Vipr1 using a luciferase gene reporter system revealed that the isolated 5'- flanking region has functional promoter activity. The mouse Vipr1 gene is encoded by a single gene, which was mapped to the distal region of mouse chromosome 9. This region is syntenic with human chromosome 3p, where the human VPAC1 receptor gene has been mapped.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalGenomics
Volume58
Issue number1
DOIs
Publication statusPublished - May 15 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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    Hashimoto, H., Nishino, A., Shintani, N., Hagihara, N., Copeland, N. G., Jenkins, N. A., Yamamoto, K., Matsuda, T., Ishihara, T., Nagata, S., & Baba, A. (1999). Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor. Genomics, 58(1), 90-93. https://doi.org/10.1006/geno.1999.5805