Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion

Misuzu Kurihara, Kagayaki Kato, Chiaki Sanbo, Shuji Shigenobu, Yasuyuki Ohkawa, Takeshi Fuchigami, Yusuke Miyanari

Research output: Contribution to journalArticle

Abstract

Kurihara et al. determined genetic loci associated with PML bodies in mouse ESCs by developing APEX-mediated chromatin labeling and purification (ALaP). PML bodies frequently associate with the short arm of the Y chromosome to regulate clustered Y-linked genes by maintaining hypo-methylated DNA through excluding DNMT3A.

Original languageEnglish
Pages (from-to)493-505.e8
JournalMolecular Cell
Volume78
Issue number3
DOIs
Publication statusPublished - May 7 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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