Germ cell specification in mice

Katsuhiko Hayashi, Susana M.Chuva De Sousa Lopes, M. Azim Surani

Research output: Contribution to journalReview article

216 Citations (Scopus)

Abstract

Specification of germ cells in mice occurs relatively late in embryonic development. It is initiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epiblast cells of early postimplantation embryos. Blimp1 represses the incipient somatic program in these cells and promotes progression toward the germ cell fate. Blimp1 may also have a role in the maintenance of early germ cell characteristics by ensuring their escape from the somatic fate as well as possible reversion to pluripotent stem cells.

Original languageEnglish
Pages (from-to)394-396
Number of pages3
JournalScience
Volume316
Issue number5823
DOIs
Publication statusPublished - Apr 20 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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    Hayashi, K., Lopes, S. M. C. D. S., & Surani, M. A. (2007). Germ cell specification in mice. Science, 316(5823), 394-396. https://doi.org/10.1126/science.1137545