Gestational choriocarcinoma whose responsible pregnancy was a complete hydatidiform mole identified by PCR analysis with new sequence tagged site primers

Yoshibumi Kaneta, Reiko Yoshiyama, Noboru Inagaki, Kiwamu Toyoshima, Kimihiko Ito, Ruriko Nishino, Hirokatsu Kitai, Hidenori Kato, Kazuo Asanoma, Norio Wake

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a case where the pregnancy responsible for a gestational choriocarcinoma was not the antecedent pregnancy or the second normal term delivery, but a complete hydatidiform mole that had advanced to clinically invasive mole. This responsible pregnancy was identified by polymerase chain reaction analysis (PCR). PCR analysis was performed by using five new sets of sequence-tagged site (STS) primers on four chromosomes (chr. 1, D1S225; chr. 3, D3S1744; chr. 12, D12S1090;chr. 18, D18S849 and D18S877). The constitution of alleles of choriocarcinoma was shown to be almost identical with that of the husband on every marker. The allele patterns of choriocarcinoma on D3S1744 and D12S1090 were not observed with DNA from the patient. The band pattern originating from molar DNA was also identical with those of the husband and choriocarcinomas on D18S849 and D1S225.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalJapanese journal of clinical oncology
Volume29
Issue number10
DOIs
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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