Giant amino acids designed on the polysaccharide scaffold and their protein-like structural interconversion

Shun Ichi Tamaru, Daisuke Tokunaga, Kaori Hori, Sayaka Matsuda, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Amphoteric β-1,3-glucans possessing both amino groups and carboxylic acid groups on the C6 positions of glucose units were designed and synthesized from naturally produced curdlan. The amphoteric polysaccharides showed the isoelectric point and the pH responsive interconversion between the original triple helix and single-stranded random structures. Since the pH dependences are comparable to the typical properties of proteins, the polysaccharides can be considered as a new class of giant amino acids. Utilizing the pH responsiveness, pH-controlled catch-and-release has been realized for cationic peptides or anionic DNA. We believe that the amphoteric polysaccharide can act as a new potential polymer to construct stimuli-responsive smart materials on the basis of the polysaccharide scaffold.

Original languageEnglish
Pages (from-to)815-822
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Giant amino acids designed on the polysaccharide scaffold and their protein-like structural interconversion'. Together they form a unique fingerprint.

Cite this