GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor

Guangchun Chen, Yutaka Goto, Ryuichi Sakamoto, Kimitaka Tanaka, Eri Matsubara, Masafumi Nakamura, Hong Zheng, Jian Lu, Ryoichi Takayanagi, Masatoshi Nomura

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Sonic hedgehog (SHH) signaling, acting in a combinatorial manner with androgen signaling, is essential for prostate patterning and development. Recently, elevated activation of SHH signaling has been shown to play important roles in proliferation, progression and metastasis of prostate cancer. In this report, we demonstrate for the first time, that GLI1, which has been shown to play a central role in SHH signaling in prostate cancer, can act as a co-repressor to substantially block androgen receptor (AR)-mediated transactivation, at least in part, by directly interacting with AR. Our observations suggest that the SHH-GLI pathway might be one of determinants governing the transition of prostate cancer from an. androgen-dependent to an androgen-independent state by compensating, or even superseding androgen signaling.

Original languageEnglish
Pages (from-to)809-815
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume404
Issue number3
DOIs
Publication statusPublished - Jan 21 2011

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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