Glibenclamide, a specific inhibitor of ATP-sensitive K+ channels, inhibits coronary vasodilation induced by angiotensin II-receptor antagonists

H. Tada, Kensuke Egashira, M. Yamamoto, H. Ueno, M. Takemoto, H. Shimokawa, A. Takeshita

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of our study was test the hypothesis that endogenous angiotensin II contributes to the basal coronary artery tone by acting at vascular ATP-sensitive K+ (K+ATP) channels. Coronary blood flow (CBF) and other hemodynamic parameters were measured in anesthetized dogs. Intracoronary infusion of the selective antagonists of angiotensin II AT1 receptors (L-158,809 and E4177) increased CBF without affecting other hemodynamic parameters, indicating that endogenous angiotensin II caused coronary vasoconstriction through the AT1 subtype receptors. Coronary vasodilation in response to AT1 receptor antagonists was blunted by pretreatment with glibenclamide (a specific inhibitor of K+ATP channels; p < 0.01) but not by either an adenosine-receptor antagonist or an inhibitor of nitric oxide synthesis. Coronary vasodilation in response to AT1-receptor antagonists was partly reduced (p < 0.01) by PD-123319 (the AT2-receptor antagonist). Glibenclamide had no effect on coronary vasodilation induced by sodium nitroprusside. These results indicate that in dogs in vivo, coronary vasodilation in response to AT1-receptor antagonists inhibited markedly by glibenclamide and partly by PD-123319, suggesting that endogenous angiotensin II contributes to the maintenance of basal coronary vascular tone by acting at K+ATP channels through its receptors.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume30
Issue number3
DOIs
Publication statusPublished - Dec 1 1997

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Glyburide
Angiotensin Receptor Antagonists
Vasodilation
Adenosine Triphosphate
Angiotensin II
Blood Vessels
Hemodynamics
Dogs
Purinergic P1 Receptor Antagonists
Angiotensin Type 1 Receptor
Angiotensin Receptors
Nitroprusside
Vasoconstriction
Coronary Vessels
Nitric Oxide
Maintenance
PD 123319

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Glibenclamide, a specific inhibitor of ATP-sensitive K+ channels, inhibits coronary vasodilation induced by angiotensin II-receptor antagonists. / Tada, H.; Egashira, Kensuke; Yamamoto, M.; Ueno, H.; Takemoto, M.; Shimokawa, H.; Takeshita, A.

In: Journal of Cardiovascular Pharmacology, Vol. 30, No. 3, 01.12.1997, p. 313-319.

Research output: Contribution to journalArticle

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