Abstract
The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 567-591 |
| Number of pages | 25 |
| Journal | Reviews in the Neurosciences |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 26 2018 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
Gliotransmitters and cytokines in the control of blood-brain barrier permeability. / Osipova, Elena D.; Semyachkina-Glushkovskaya, Oxana V.; Morgun, Andrey V.; Pisareva, Natalia V.; Malinovskaya, Natalia A.; Boitsova, Elizaveta B.; Pozhilenkova, Elena A.; Belova, Olga A.; Salmin, Vladimir V.; Taranushenko, Tatiana E.; Noda, Mami; Salmina, Alla B.
In: Reviews in the Neurosciences, Vol. 29, No. 5, 26.07.2018, p. 567-591.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gliotransmitters and cytokines in the control of blood-brain barrier permeability
AU - Osipova, Elena D.
AU - Semyachkina-Glushkovskaya, Oxana V.
AU - Morgun, Andrey V.
AU - Pisareva, Natalia V.
AU - Malinovskaya, Natalia A.
AU - Boitsova, Elizaveta B.
AU - Pozhilenkova, Elena A.
AU - Belova, Olga A.
AU - Salmin, Vladimir V.
AU - Taranushenko, Tatiana E.
AU - Noda, Mami
AU - Salmina, Alla B.
PY - 2018/7/26
Y1 - 2018/7/26
N2 - The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.
AB - The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.
UR - http://www.scopus.com/inward/record.url?scp=85040938415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040938415&partnerID=8YFLogxK
U2 - 10.1515/revneuro-2017-0092
DO - 10.1515/revneuro-2017-0092
M3 - Article
C2 - 29306934
AN - SCOPUS:85040938415
VL - 29
SP - 567
EP - 591
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
SN - 0334-1763
IS - 5
ER -