Gliotransmitters and cytokines in the control of blood-brain barrier permeability

Elena D. Osipova, Oxana V. Semyachkina-Glushkovskaya, Andrey V. Morgun, Natalia V. Pisareva, Natalia A. Malinovskaya, Elizaveta B. Boitsova, Elena A. Pozhilenkova, Olga A. Belova, Vladimir V. Salmin, Tatiana E. Taranushenko, Mami Noda, Alla B. Salmina

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.

Original languageEnglish
Pages (from-to)567-591
Number of pages25
JournalReviews in the Neurosciences
Volume29
Issue number5
DOIs
Publication statusPublished - Jul 26 2018

Fingerprint

Blood-Brain Barrier
Permeability
Cytokines
Neuroglia
Amino Acid Transport System X-AG
Connexins
Microglia
Astrocytes
Inflammasomes
Pericytes
Neuronal Plasticity
Exocytosis
Brain
Brain Diseases
Microvessels
Endothelial Cells
Macrophages
Pathology
Membranes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Osipova, E. D., Semyachkina-Glushkovskaya, O. V., Morgun, A. V., Pisareva, N. V., Malinovskaya, N. A., Boitsova, E. B., ... Salmina, A. B. (2018). Gliotransmitters and cytokines in the control of blood-brain barrier permeability. Reviews in the Neurosciences, 29(5), 567-591. https://doi.org/10.1515/revneuro-2017-0092

Gliotransmitters and cytokines in the control of blood-brain barrier permeability. / Osipova, Elena D.; Semyachkina-Glushkovskaya, Oxana V.; Morgun, Andrey V.; Pisareva, Natalia V.; Malinovskaya, Natalia A.; Boitsova, Elizaveta B.; Pozhilenkova, Elena A.; Belova, Olga A.; Salmin, Vladimir V.; Taranushenko, Tatiana E.; Noda, Mami; Salmina, Alla B.

In: Reviews in the Neurosciences, Vol. 29, No. 5, 26.07.2018, p. 567-591.

Research output: Contribution to journalArticle

Osipova, ED, Semyachkina-Glushkovskaya, OV, Morgun, AV, Pisareva, NV, Malinovskaya, NA, Boitsova, EB, Pozhilenkova, EA, Belova, OA, Salmin, VV, Taranushenko, TE, Noda, M & Salmina, AB 2018, 'Gliotransmitters and cytokines in the control of blood-brain barrier permeability', Reviews in the Neurosciences, vol. 29, no. 5, pp. 567-591. https://doi.org/10.1515/revneuro-2017-0092
Osipova ED, Semyachkina-Glushkovskaya OV, Morgun AV, Pisareva NV, Malinovskaya NA, Boitsova EB et al. Gliotransmitters and cytokines in the control of blood-brain barrier permeability. Reviews in the Neurosciences. 2018 Jul 26;29(5):567-591. https://doi.org/10.1515/revneuro-2017-0092
Osipova, Elena D. ; Semyachkina-Glushkovskaya, Oxana V. ; Morgun, Andrey V. ; Pisareva, Natalia V. ; Malinovskaya, Natalia A. ; Boitsova, Elizaveta B. ; Pozhilenkova, Elena A. ; Belova, Olga A. ; Salmin, Vladimir V. ; Taranushenko, Tatiana E. ; Noda, Mami ; Salmina, Alla B. / Gliotransmitters and cytokines in the control of blood-brain barrier permeability. In: Reviews in the Neurosciences. 2018 ; Vol. 29, No. 5. pp. 567-591.
@article{27a9684f107c4db9be585bfe394f526d,
title = "Gliotransmitters and cytokines in the control of blood-brain barrier permeability",
abstract = "The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.",
author = "Osipova, {Elena D.} and Semyachkina-Glushkovskaya, {Oxana V.} and Morgun, {Andrey V.} and Pisareva, {Natalia V.} and Malinovskaya, {Natalia A.} and Boitsova, {Elizaveta B.} and Pozhilenkova, {Elena A.} and Belova, {Olga A.} and Salmin, {Vladimir V.} and Taranushenko, {Tatiana E.} and Mami Noda and Salmina, {Alla B.}",
year = "2018",
month = "7",
day = "26",
doi = "10.1515/revneuro-2017-0092",
language = "English",
volume = "29",
pages = "567--591",
journal = "Reviews in the Neurosciences",
issn = "0334-1763",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "5",

}

TY - JOUR

T1 - Gliotransmitters and cytokines in the control of blood-brain barrier permeability

AU - Osipova, Elena D.

AU - Semyachkina-Glushkovskaya, Oxana V.

AU - Morgun, Andrey V.

AU - Pisareva, Natalia V.

AU - Malinovskaya, Natalia A.

AU - Boitsova, Elizaveta B.

AU - Pozhilenkova, Elena A.

AU - Belova, Olga A.

AU - Salmin, Vladimir V.

AU - Taranushenko, Tatiana E.

AU - Noda, Mami

AU - Salmina, Alla B.

PY - 2018/7/26

Y1 - 2018/7/26

N2 - The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.

AB - The contribution of astrocytes and microglia to the regulation of neuroplasticity or neurovascular unit (NVU) is based on the coordinated secretion of gliotransmitters and cytokines and the release and uptake of metabolites. Blood-brain barrier (BBB) integrity and angiogenesis are influenced by perivascular cells contacting with the abluminal side of brain microvessel endothelial cells (pericytes, astrocytes) or by immune cells existing (microglia) or invading the NVU (macrophages) under pathologic conditions. The release of gliotransmitters or cytokines by activated astroglial and microglial cells is provided by distinct mechanisms, affects intercellular communication, and results in the establishment of microenvironment controlling BBB permeability and neuroinflammation. Glial glutamate transporters and connexin and pannexin hemichannels working in the tight functional coupling with the purinergic system serve as promising molecular targets for manipulating the intercellular communications that control BBB permeability in brain pathologies associated with excessive angiogenesis, cerebrovascular remodeling, and BBB-mediated neuroinflammation. Substantial progress in deciphering the molecular mechanisms underlying the (patho)physiology of perivascular glia provides promising approaches to novel clinically relevant therapies for brain disorders. The present review summarizes the current understandings on the secretory machinery expressed in glial cells (glutamate transporters, connexin and pannexin hemichannels, exocytosis mechanisms, membrane-derived microvesicles, and inflammasomes) and the role of secreted gliotransmitters and cytokines in the regulation of NVU and BBB permeability in (patho)physiologic conditions.

UR - http://www.scopus.com/inward/record.url?scp=85040938415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040938415&partnerID=8YFLogxK

U2 - 10.1515/revneuro-2017-0092

DO - 10.1515/revneuro-2017-0092

M3 - Article

C2 - 29306934

AN - SCOPUS:85040938415

VL - 29

SP - 567

EP - 591

JO - Reviews in the Neurosciences

JF - Reviews in the Neurosciences

SN - 0334-1763

IS - 5

ER -