Global Outcome Assessment Life-long after stroke in young adults initiative - The GOAL initiative: Study protocol and rationale of a multicentre retrospective individual patient data meta-analysis

Merel Ekker, Mina Jacob, Myrna Van Dongen, Karoliina Aarnio, Arunkar Annamalai, Antonio Arauz, Marcel Arnold, Miguel Barboza, Manuel Bolognese, Raf Brouns, Batnairamdal Chuluun, Enkhzaya Chuluunbaatar, Byambasuren Dagvajantsan, Stephanie Debette, Adi Don, Chris Enzinger, Esme Ekizoglu, Simon Fandler-Höfler, Franz Fazekas, Anette FrommThomas Gattringer, Giosue Gulli, Michael Hoffmann, Thiago Hora, Christina Jern, Katarina Jood, Masahiro Kamouchi, Young Seo Kim, Takanari Kitazono, Steven Kittner, Timothy Kleinig, Karin Klijn, Janika Korv, Tsong Hai Lee, Didier Leys, Noortje Maaijwee, Nicolas Martinez-Majander, João Pedro Marto, M. Mehndiratta, Victoria Mifsud, Vinicius Montanaro, M. O. Owolabi, Vinod Patel, Matthew Phillips, Bartlomiej Piechowski-Iozwiak, Aleksandra Pikula, Jose Luis Ruiz-Sandoval, Bettina Sarnowski, Floris Schreuder, Rick Swartz, K. S. Tan, David Tanne, T. Tatlisumak, Vincent Thijs, Anil Tuladhar, Miguel Viana-Baptista, Riina Vibo, Teddy Wu, Nilüfer Yesilot, Ulrike Waje-Andreassen, Alessandro Pezzini, Jukka Putaala, Frank Erik De Leeuw

Research output: Contribution to journalArticle

Abstract

Introduction Worldwide, 2 million patients aged 18-50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of appropriate information regarding the causes of stroke, risk factors and prognosis of young stroke patients. Methods and analysis The Global Outcome Assessment Life-long after stroke in young adults (GOAL) initiative aims to perform a global individual patient data meta-analysis with existing data from young stroke cohorts worldwide. All patients aged 18-50 years with ischaemic stroke or intracerebral haemorrhage will be included. Outcomes will be the distribution of stroke aetiology and (vascular) risk factors, functional outcome after stroke, risk of recurrent vascular events and death and finally the use of secondary prevention. Subgroup analyses will be made based on age, gender, aetiology, ethnicity and climate of residence. Ethics and dissemination Ethical approval for the GOAL study has already been obtained from the Medical Review Ethics Committee region Arnhem-Nijmegen. Additionally and when necessary, approval will also be obtained from national or local institutional review boards in the participating centres. When needed, a standardised data transfer agreement will be provided for participating centres. We plan dissemination of our results in peer-reviewed international scientific journals and through conference presentations. We expect that the results of this unique study will lead to better understanding of worldwide differences in risk factors, causes and outcome of young stroke patients.

Original languageEnglish
Article numbere031144
JournalBMJ open
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2019

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Meta-Analysis
Young Adult
Stroke
Outcome Assessment (Health Care)
Secondary Prevention
Transfer Agreement
Ethics Committees
Medical Ethics
Research Ethics Committees
Cerebral Hemorrhage
Advisory Committees
Climate
Ethics
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Global Outcome Assessment Life-long after stroke in young adults initiative - The GOAL initiative : Study protocol and rationale of a multicentre retrospective individual patient data meta-analysis. / Ekker, Merel; Jacob, Mina; Van Dongen, Myrna; Aarnio, Karoliina; Annamalai, Arunkar; Arauz, Antonio; Arnold, Marcel; Barboza, Miguel; Bolognese, Manuel; Brouns, Raf; Chuluun, Batnairamdal; Chuluunbaatar, Enkhzaya; Dagvajantsan, Byambasuren; Debette, Stephanie; Don, Adi; Enzinger, Chris; Ekizoglu, Esme; Fandler-Höfler, Simon; Fazekas, Franz; Fromm, Anette; Gattringer, Thomas; Gulli, Giosue; Hoffmann, Michael; Hora, Thiago; Jern, Christina; Jood, Katarina; Kamouchi, Masahiro; Kim, Young Seo; Kitazono, Takanari; Kittner, Steven; Kleinig, Timothy; Klijn, Karin; Korv, Janika; Lee, Tsong Hai; Leys, Didier; Maaijwee, Noortje; Martinez-Majander, Nicolas; Marto, João Pedro; Mehndiratta, M.; Mifsud, Victoria; Montanaro, Vinicius; Owolabi, M. O.; Patel, Vinod; Phillips, Matthew; Piechowski-Iozwiak, Bartlomiej; Pikula, Aleksandra; Ruiz-Sandoval, Jose Luis; Sarnowski, Bettina; Schreuder, Floris; Swartz, Rick; Tan, K. S.; Tanne, David; Tatlisumak, T.; Thijs, Vincent; Tuladhar, Anil; Viana-Baptista, Miguel; Vibo, Riina; Wu, Teddy; Yesilot, Nilüfer; Waje-Andreassen, Ulrike; Pezzini, Alessandro; Putaala, Jukka; De Leeuw, Frank Erik.

In: BMJ open, Vol. 9, No. 11, e031144, 01.11.2019.

Research output: Contribution to journalArticle

Ekker, M, Jacob, M, Van Dongen, M, Aarnio, K, Annamalai, A, Arauz, A, Arnold, M, Barboza, M, Bolognese, M, Brouns, R, Chuluun, B, Chuluunbaatar, E, Dagvajantsan, B, Debette, S, Don, A, Enzinger, C, Ekizoglu, E, Fandler-Höfler, S, Fazekas, F, Fromm, A, Gattringer, T, Gulli, G, Hoffmann, M, Hora, T, Jern, C, Jood, K, Kamouchi, M, Kim, YS, Kitazono, T, Kittner, S, Kleinig, T, Klijn, K, Korv, J, Lee, TH, Leys, D, Maaijwee, N, Martinez-Majander, N, Marto, JP, Mehndiratta, M, Mifsud, V, Montanaro, V, Owolabi, MO, Patel, V, Phillips, M, Piechowski-Iozwiak, B, Pikula, A, Ruiz-Sandoval, JL, Sarnowski, B, Schreuder, F, Swartz, R, Tan, KS, Tanne, D, Tatlisumak, T, Thijs, V, Tuladhar, A, Viana-Baptista, M, Vibo, R, Wu, T, Yesilot, N, Waje-Andreassen, U, Pezzini, A, Putaala, J & De Leeuw, FE 2019, 'Global Outcome Assessment Life-long after stroke in young adults initiative - The GOAL initiative: Study protocol and rationale of a multicentre retrospective individual patient data meta-analysis', BMJ open, vol. 9, no. 11, e031144. https://doi.org/10.1136/bmjopen-2019-031144
Ekker, Merel ; Jacob, Mina ; Van Dongen, Myrna ; Aarnio, Karoliina ; Annamalai, Arunkar ; Arauz, Antonio ; Arnold, Marcel ; Barboza, Miguel ; Bolognese, Manuel ; Brouns, Raf ; Chuluun, Batnairamdal ; Chuluunbaatar, Enkhzaya ; Dagvajantsan, Byambasuren ; Debette, Stephanie ; Don, Adi ; Enzinger, Chris ; Ekizoglu, Esme ; Fandler-Höfler, Simon ; Fazekas, Franz ; Fromm, Anette ; Gattringer, Thomas ; Gulli, Giosue ; Hoffmann, Michael ; Hora, Thiago ; Jern, Christina ; Jood, Katarina ; Kamouchi, Masahiro ; Kim, Young Seo ; Kitazono, Takanari ; Kittner, Steven ; Kleinig, Timothy ; Klijn, Karin ; Korv, Janika ; Lee, Tsong Hai ; Leys, Didier ; Maaijwee, Noortje ; Martinez-Majander, Nicolas ; Marto, João Pedro ; Mehndiratta, M. ; Mifsud, Victoria ; Montanaro, Vinicius ; Owolabi, M. O. ; Patel, Vinod ; Phillips, Matthew ; Piechowski-Iozwiak, Bartlomiej ; Pikula, Aleksandra ; Ruiz-Sandoval, Jose Luis ; Sarnowski, Bettina ; Schreuder, Floris ; Swartz, Rick ; Tan, K. S. ; Tanne, David ; Tatlisumak, T. ; Thijs, Vincent ; Tuladhar, Anil ; Viana-Baptista, Miguel ; Vibo, Riina ; Wu, Teddy ; Yesilot, Nilüfer ; Waje-Andreassen, Ulrike ; Pezzini, Alessandro ; Putaala, Jukka ; De Leeuw, Frank Erik. / Global Outcome Assessment Life-long after stroke in young adults initiative - The GOAL initiative : Study protocol and rationale of a multicentre retrospective individual patient data meta-analysis. In: BMJ open. 2019 ; Vol. 9, No. 11.
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abstract = "Introduction Worldwide, 2 million patients aged 18-50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of appropriate information regarding the causes of stroke, risk factors and prognosis of young stroke patients. Methods and analysis The Global Outcome Assessment Life-long after stroke in young adults (GOAL) initiative aims to perform a global individual patient data meta-analysis with existing data from young stroke cohorts worldwide. All patients aged 18-50 years with ischaemic stroke or intracerebral haemorrhage will be included. Outcomes will be the distribution of stroke aetiology and (vascular) risk factors, functional outcome after stroke, risk of recurrent vascular events and death and finally the use of secondary prevention. Subgroup analyses will be made based on age, gender, aetiology, ethnicity and climate of residence. Ethics and dissemination Ethical approval for the GOAL study has already been obtained from the Medical Review Ethics Committee region Arnhem-Nijmegen. Additionally and when necessary, approval will also be obtained from national or local institutional review boards in the participating centres. When needed, a standardised data transfer agreement will be provided for participating centres. We plan dissemination of our results in peer-reviewed international scientific journals and through conference presentations. We expect that the results of this unique study will lead to better understanding of worldwide differences in risk factors, causes and outcome of young stroke patients.",
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TY - JOUR

T1 - Global Outcome Assessment Life-long after stroke in young adults initiative - The GOAL initiative

T2 - Study protocol and rationale of a multicentre retrospective individual patient data meta-analysis

AU - Ekker, Merel

AU - Jacob, Mina

AU - Van Dongen, Myrna

AU - Aarnio, Karoliina

AU - Annamalai, Arunkar

AU - Arauz, Antonio

AU - Arnold, Marcel

AU - Barboza, Miguel

AU - Bolognese, Manuel

AU - Brouns, Raf

AU - Chuluun, Batnairamdal

AU - Chuluunbaatar, Enkhzaya

AU - Dagvajantsan, Byambasuren

AU - Debette, Stephanie

AU - Don, Adi

AU - Enzinger, Chris

AU - Ekizoglu, Esme

AU - Fandler-Höfler, Simon

AU - Fazekas, Franz

AU - Fromm, Anette

AU - Gattringer, Thomas

AU - Gulli, Giosue

AU - Hoffmann, Michael

AU - Hora, Thiago

AU - Jern, Christina

AU - Jood, Katarina

AU - Kamouchi, Masahiro

AU - Kim, Young Seo

AU - Kitazono, Takanari

AU - Kittner, Steven

AU - Kleinig, Timothy

AU - Klijn, Karin

AU - Korv, Janika

AU - Lee, Tsong Hai

AU - Leys, Didier

AU - Maaijwee, Noortje

AU - Martinez-Majander, Nicolas

AU - Marto, João Pedro

AU - Mehndiratta, M.

AU - Mifsud, Victoria

AU - Montanaro, Vinicius

AU - Owolabi, M. O.

AU - Patel, Vinod

AU - Phillips, Matthew

AU - Piechowski-Iozwiak, Bartlomiej

AU - Pikula, Aleksandra

AU - Ruiz-Sandoval, Jose Luis

AU - Sarnowski, Bettina

AU - Schreuder, Floris

AU - Swartz, Rick

AU - Tan, K. S.

AU - Tanne, David

AU - Tatlisumak, T.

AU - Thijs, Vincent

AU - Tuladhar, Anil

AU - Viana-Baptista, Miguel

AU - Vibo, Riina

AU - Wu, Teddy

AU - Yesilot, Nilüfer

AU - Waje-Andreassen, Ulrike

AU - Pezzini, Alessandro

AU - Putaala, Jukka

AU - De Leeuw, Frank Erik

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Introduction Worldwide, 2 million patients aged 18-50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of appropriate information regarding the causes of stroke, risk factors and prognosis of young stroke patients. Methods and analysis The Global Outcome Assessment Life-long after stroke in young adults (GOAL) initiative aims to perform a global individual patient data meta-analysis with existing data from young stroke cohorts worldwide. All patients aged 18-50 years with ischaemic stroke or intracerebral haemorrhage will be included. Outcomes will be the distribution of stroke aetiology and (vascular) risk factors, functional outcome after stroke, risk of recurrent vascular events and death and finally the use of secondary prevention. Subgroup analyses will be made based on age, gender, aetiology, ethnicity and climate of residence. Ethics and dissemination Ethical approval for the GOAL study has already been obtained from the Medical Review Ethics Committee region Arnhem-Nijmegen. Additionally and when necessary, approval will also be obtained from national or local institutional review boards in the participating centres. When needed, a standardised data transfer agreement will be provided for participating centres. We plan dissemination of our results in peer-reviewed international scientific journals and through conference presentations. We expect that the results of this unique study will lead to better understanding of worldwide differences in risk factors, causes and outcome of young stroke patients.

AB - Introduction Worldwide, 2 million patients aged 18-50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of appropriate information regarding the causes of stroke, risk factors and prognosis of young stroke patients. Methods and analysis The Global Outcome Assessment Life-long after stroke in young adults (GOAL) initiative aims to perform a global individual patient data meta-analysis with existing data from young stroke cohorts worldwide. All patients aged 18-50 years with ischaemic stroke or intracerebral haemorrhage will be included. Outcomes will be the distribution of stroke aetiology and (vascular) risk factors, functional outcome after stroke, risk of recurrent vascular events and death and finally the use of secondary prevention. Subgroup analyses will be made based on age, gender, aetiology, ethnicity and climate of residence. Ethics and dissemination Ethical approval for the GOAL study has already been obtained from the Medical Review Ethics Committee region Arnhem-Nijmegen. Additionally and when necessary, approval will also be obtained from national or local institutional review boards in the participating centres. When needed, a standardised data transfer agreement will be provided for participating centres. We plan dissemination of our results in peer-reviewed international scientific journals and through conference presentations. We expect that the results of this unique study will lead to better understanding of worldwide differences in risk factors, causes and outcome of young stroke patients.

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U2 - 10.1136/bmjopen-2019-031144

DO - 10.1136/bmjopen-2019-031144

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JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

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