Glucagon underutilized among type 1 diabetes mellitus patients in Japan

Takashi Murata, Kentaro Okazaki, Katsuyuki Yanagisawa, Kenichi Yamada, Nobuichi Kuribayashi, Yasuo Totsuka, Toru Hiyoshi, Motoji Naka, Masatake Sugimoto, Yuji Aoki, Masako Waki, Miyuki Furuya, Haruko Kitaoka, Mariko Oishi, Ikki Shimizu, Hiroaki Miyaoka, Toshikazu Yamamoto, Kazunori Yamada, Naoki Sakane

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Aim: Glucagon is recommended to treat severe hypoglycemia in nonhospital environments, when a patient with type 1 diabetes mellitus (T1DM) is unconscious and unable to eat or drink. However, the actual possession rate of glucagon in Japan has not been investigated. Subjects and Methods: We recruited 208 T1DM patients older than 15 years of age. The patients were treated at 16 hospitals and clinics in different regions of Japan. Answers were obtained using a self-Administered questionnaire about the possession, the experience of usage, and the preference to possess glucagon after reading what is glucagon and when it is used. A stepwise logistic regression analysis was performed to assess the influence of various factors on the possession of glucagon. Results: The possession rate of glucagon was 15.9%, and the rate of those who had experience of using glucagon to treat severe hypoglycemia was 6.0%. The rate of preference to possess glucagon at home after reading the description of glucagon was 39.0%. The possession of glucagon was significantly associated with results of the Glucagon Knowledge Test (odds ratio=24.1; 95% confidence interval, 3.2-183.3; P=0.002) and the history of severe hypoglycemia within 1 year (odds ratio=4.8; 95% confidence interval, 2.0-12.0; P=0.001). Conclusions: Glucagon as a measure to treat severe hypoglycemia was underutilized among T1DM patients in Japan.

Original languageEnglish
Pages (from-to)748-750
Number of pages3
JournalDiabetes Technology and Therapeutics
Issue number9
Publication statusPublished - Sep 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Medical Laboratory Technology


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