Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver

Koyanagi Satoru, Hinako Suyama, Yukako Kuramoto, Matsunaga Naoya, Hiroshi Takane, Shinji Soeda, Hiroshi Shimeno, Shun Higuchi, Shigehiro Ohdo

Research output: Contribution to journalArticle

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Abstract

Although the antiviral effect of interferon (IFN) varies depending on 24-h oscillation in the expression of its specific receptor, the mechanism of oscillation remains to be clarified. Here we report that oscillation in the expression of the IFN receptor gene (IFN-α/β R1) in mouse liver is caused by the endogenous rhythm of glucocorticoid secretion. Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-α/β R1. The CORT-induced decrease in IFN-α/β R1 mRNA levels was reversed by pretreating the cells with RU486, a glucocorticoid receptor antagonist. The mRNA levels of IFN-α/β R1 gene in the liver of adrenalectomized mice were consistently increased throughout the day. However, a single administration of CORT to adrenalectomized mice significantly decreased the mRNA levels of IFN-α/β R1 in the liver. Furthermore, the rhythmic phase of IFN-α/β R1 expression was modulated after the alteration of rhythmicity in glucocorticoid secretion, which was induced by restricted daily feeding. As a consequence, under manipulation of the feeding schedule, 2′-5′ oligoadenylate synthase activities, as an index of antiviral effect, in plasma and liver at 24 h after IFN-α injection also varied depending on the alteration of glucocorticoid secretion rhythm. These results suggest that the endogenous rhythm of glucocorticoid secretion is involved in the circadian regulation of IFN-α/β R1 expression in mouse liver. Our findings also support the notion that monitoring the 24-h variation in IFN receptor function is useful for selecting the most appropriate time of day to administer IFN.

Original languageEnglish
Pages (from-to)5034-5040
Number of pages7
JournalEndocrinology
Volume147
Issue number11
DOIs
Publication statusPublished - Nov 27 2006

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Interferon Receptors
Interferons
Glucocorticoids
Gene Expression
Liver
Corticosterone
Messenger RNA
Antiviral Agents
Glucocorticoid Receptors
Periodicity
Genes
Hepatocytes
Appointments and Schedules

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. / Satoru, Koyanagi; Suyama, Hinako; Kuramoto, Yukako; Naoya, Matsunaga; Takane, Hiroshi; Soeda, Shinji; Shimeno, Hiroshi; Higuchi, Shun; Ohdo, Shigehiro.

In: Endocrinology, Vol. 147, No. 11, 27.11.2006, p. 5034-5040.

Research output: Contribution to journalArticle

Satoru, Koyanagi ; Suyama, Hinako ; Kuramoto, Yukako ; Naoya, Matsunaga ; Takane, Hiroshi ; Soeda, Shinji ; Shimeno, Hiroshi ; Higuchi, Shun ; Ohdo, Shigehiro. / Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. In: Endocrinology. 2006 ; Vol. 147, No. 11. pp. 5034-5040.
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