Glucocorticoid regulation of leptin synthesis and secretion in humans

Elevated plasma leptin levels in Cushing's syndrome

Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda, Takashi Miyawaki, Ikuko Hanaoka, Junko Hiraoka, Akiko Yasuno, Haruo Nishimura, Yasunao Yoshimasa, Shigeo Nishi, Kazuwa Nakao

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome wore significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the admistration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.

Original languageEnglish
Pages (from-to)2542-2547
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume82
Issue number8
DOIs
Publication statusPublished - Aug 22 1997

Fingerprint

Plasma (human)
Cushing Syndrome
Leptin
Glucocorticoids
Plasmas
Adipose Tissue
Pituitary Neoplasms
Dexamethasone
Healthy Volunteers
Tissue
Endocrine System Diseases
Body Weight Changes
Organ Culture Techniques
Metabolic Diseases
Adipocytes
Gene expression
Hydrocortisone
Tumors
Eating
Fats

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome. / Masuzaki, Hiroaki; Ogawa, Yoshihiro; Hosoda, Kiminori; Miyawaki, Takashi; Hanaoka, Ikuko; Hiraoka, Junko; Yasuno, Akiko; Nishimura, Haruo; Yoshimasa, Yasunao; Nishi, Shigeo; Nakao, Kazuwa.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 82, No. 8, 22.08.1997, p. 2542-2547.

Research output: Contribution to journalArticle

Masuzaki, H, Ogawa, Y, Hosoda, K, Miyawaki, T, Hanaoka, I, Hiraoka, J, Yasuno, A, Nishimura, H, Yoshimasa, Y, Nishi, S & Nakao, K 1997, 'Glucocorticoid regulation of leptin synthesis and secretion in humans: Elevated plasma leptin levels in Cushing's syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 8, pp. 2542-2547. https://doi.org/10.1210/jc.82.8.2542
Masuzaki, Hiroaki ; Ogawa, Yoshihiro ; Hosoda, Kiminori ; Miyawaki, Takashi ; Hanaoka, Ikuko ; Hiraoka, Junko ; Yasuno, Akiko ; Nishimura, Haruo ; Yoshimasa, Yasunao ; Nishi, Shigeo ; Nakao, Kazuwa. / Glucocorticoid regulation of leptin synthesis and secretion in humans : Elevated plasma leptin levels in Cushing's syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1997 ; Vol. 82, No. 8. pp. 2542-2547.
@article{1e8a7337e4944d818795ca6c51a14c4c,
title = "Glucocorticoid regulation of leptin synthesis and secretion in humans: Elevated plasma leptin levels in Cushing's syndrome",
abstract = "Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome wore significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the admistration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.",
author = "Hiroaki Masuzaki and Yoshihiro Ogawa and Kiminori Hosoda and Takashi Miyawaki and Ikuko Hanaoka and Junko Hiraoka and Akiko Yasuno and Haruo Nishimura and Yasunao Yoshimasa and Shigeo Nishi and Kazuwa Nakao",
year = "1997",
month = "8",
day = "22",
doi = "10.1210/jc.82.8.2542",
language = "English",
volume = "82",
pages = "2542--2547",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "8",

}

TY - JOUR

T1 - Glucocorticoid regulation of leptin synthesis and secretion in humans

T2 - Elevated plasma leptin levels in Cushing's syndrome

AU - Masuzaki, Hiroaki

AU - Ogawa, Yoshihiro

AU - Hosoda, Kiminori

AU - Miyawaki, Takashi

AU - Hanaoka, Ikuko

AU - Hiraoka, Junko

AU - Yasuno, Akiko

AU - Nishimura, Haruo

AU - Yoshimasa, Yasunao

AU - Nishi, Shigeo

AU - Nakao, Kazuwa

PY - 1997/8/22

Y1 - 1997/8/22

N2 - Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome wore significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the admistration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.

AB - Leptin, the obese (ob) gene product, is an adipocyte-derived satiety factor that is involved in the regulation of food ingestion and body weight. To investigate glucocorticoid regulation of leptin synthesis and secretion in humans, we measured plasma leptin levels in patients with Cushing's syndrome with adrenal or pituitary adenoma and in patients with iatrogenic Cushing's syndrome. Plasma leptin levels in patients with Cushing's syndrome wore significantly elevated compared to those in nonobese healthy subjects and obese subjects without any metabolic or endocrine diseases at a given percentage of body fat by analysis of covariance. In patients with adrenal or pituitary adenoma, after the tumor resection, plasma leptin levels were reduced, with a concurrent decrease in plasma cortisol levels. With no significant changes in body weight, plasma leptin levels were also elevated significantly in lean healthy volunteers 24 h after the admistration of 1 mg dexamethasone. Dexamethasone potently induced ob gene expression and leptin secretion in the organ culture of human adipose tissue. The data demonstrate that glucocorticoids act, at least in part, directly on the adipose tissue and increase leptin synthesis and secretion in humans.

UR - http://www.scopus.com/inward/record.url?scp=8544258847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8544258847&partnerID=8YFLogxK

U2 - 10.1210/jc.82.8.2542

DO - 10.1210/jc.82.8.2542

M3 - Article

VL - 82

SP - 2542

EP - 2547

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -