TY - JOUR
T1 - Glucose signaling in the brain and periphery to memory
AU - Hossain, Md Shamim
AU - Oomura, Yutaka
AU - Fujino, Takehiko
AU - Akashi, Koichi
N1 - Funding Information:
M.S.H. has received grant from the JSPS Wakate B ( 16K19007 ) and Grant-in-Aid for JSPS Fellows ( 13F03094 ). We thank Ako Niwase, Yuki Yoneya, Marcus Leiwe, and Chizuko Kanemaru for the review and correction of English.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/3
Y1 - 2020/3
N2 - Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
AB - Glucose has many diverse physiological roles such as energy metabolism, appetite control and memory consolidation. We recently reported that memory-related gene expression is epigenetically controlled in murine brain cells and that glucose can regulate gene expression in a cell-specific manner. However, the literature reviews have indicated that glucose can also regulate gut cells to release incretins which might play a role in memory processes directly or indirectly by vagus nerve stimulation. In this review, we discussed the effects of glucose on the gut and brain, aiming to understand more in-depth the role of glucose in memory function. In addition, we also discussed the alteration of glucose-signaling in type-2 diabetes mellitus (T2DM) and a possible link to Alzheimer's disease (AD) pathologies.
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U2 - 10.1016/j.neubiorev.2019.03.018
DO - 10.1016/j.neubiorev.2019.03.018
M3 - Review article
C2 - 32111301
AN - SCOPUS:85081071974
SN - 0149-7634
VL - 110
SP - 100
EP - 113
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -
