Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG

Motofumi Kumazoe, Yasutake Tanaka, Ren Yoshitomi, Yuki Marugame, Kwan Woo Lee, Hiroaki Onda, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Hirofumi Tachibana

Research output: Contribution to journalComment/debatepeer-review

Abstract

Animal and clinical studies have revealed that (–)-epigallocatechin-3-O-gallate (EGCG), one of the major bioactive polyphenols in green tea, showed several pharmacological effects including anti-obesity effect and anti-inflammatory effect. We previously reported that the second messenger cyclic guanosine monophosphate (cGMP) mediates its anti-inflammatory and anti-cancer properties. Here we demonstrated that glucosyl-hesperidin, enhances the cGMP-inducing effects of green tea extract in vivo. Moreover, glucosyl-hesperidin intake potentiated the green tea-elicited upregulation of the anti-inflammatory factor, toll-interacting protein.

Original languageEnglish
Pages (from-to)1037-1042
Number of pages6
JournalJournal of Natural Medicines
Volume75
Issue number4
DOIs
Publication statusPublished - Sep 2021

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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