Glutamate receptor subtypes may be classified into two major categories: A study on Xenopus oocytes injected with rat brain mRNA

Hiroyuki Sugiyama, Isao Ito, Masakazu Watanabe

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Three major subtypes of glutamate receptors that are coupled to cation channels are known. Recently an additional subtype that is coupled to G proteins and stimulates inositol phospholipid metabolism (the metabotropic glutamate receptor) has been proposed. The pharmacological characteristics of this receptor have now been examined. Although it shares some agonists with N-methyl-d-aspartate- and quisqualate-subtype receptors, it shares virtually no antagonists with any of the three cation channel-coupled receptor subtypes. Thus the metabotropic glutamate receptor belongs to a receptor category that is completely different from that of the other three receptor subtypes, not only functionally, but also pharmacologically.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalNeuron
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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Metabotropic Glutamate Receptors
Glutamate Receptors
Xenopus
Oocytes
Cations
Messenger RNA
AMPA Receptors
Brain
Phosphatidylinositols
GTP-Binding Proteins
Aspartic Acid
Pharmacology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Glutamate receptor subtypes may be classified into two major categories : A study on Xenopus oocytes injected with rat brain mRNA. / Sugiyama, Hiroyuki; Ito, Isao; Watanabe, Masakazu.

In: Neuron, Vol. 3, No. 1, 01.01.1989, p. 129-132.

Research output: Contribution to journalArticle

Sugiyama, Hiroyuki ; Ito, Isao ; Watanabe, Masakazu. / Glutamate receptor subtypes may be classified into two major categories : A study on Xenopus oocytes injected with rat brain mRNA. In: Neuron. 1989 ; Vol. 3, No. 1. pp. 129-132.
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