Abstract
A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.
| Original language | English |
|---|---|
| Pages (from-to) | 1058-1061 |
| Number of pages | 4 |
| Journal | Chemistry Letters |
| Volume | 48 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)
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Matsune, H., Ono, T., Yoshida, R., Yamamoto, T., & Kishida, M. (2019). Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier. Chemistry Letters, 48(9), 1058-1061. https://doi.org/10.1246/cl.190353