Abstract
A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.
| Original language | English |
|---|---|
| Pages (from-to) | 1058-1061 |
| Number of pages | 4 |
| Journal | Chemistry Letters |
| Volume | 48 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
Cite this
Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier. / Matsune, Hideki; Ono, Tomoya; Yoshida, Ryoya; Yamamoto, Tsuyoshi; Kishida, Masahiro.
In: Chemistry Letters, Vol. 48, No. 9, 01.01.2019, p. 1058-1061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier
AU - Matsune, Hideki
AU - Ono, Tomoya
AU - Yoshida, Ryoya
AU - Yamamoto, Tsuyoshi
AU - Kishida, Masahiro
PY - 2019/1/1
Y1 - 2019/1/1
N2 - A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.
AB - A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.
UR - http://www.scopus.com/inward/record.url?scp=85070783064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070783064&partnerID=8YFLogxK
U2 - 10.1246/cl.190353
DO - 10.1246/cl.190353
M3 - Article
AN - SCOPUS:85070783064
VL - 48
SP - 1058
EP - 1061
JO - Chemistry Letters
JF - Chemistry Letters
SN - 0366-7022
IS - 9
ER -