Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier

Hideki Matsune, Tomoya Ono, Ryoya Yoshida, Tsuyoshi Yamamoto, Masahiro Kishida

Research output: Contribution to journalArticle

Abstract

A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.

Original languageEnglish
Pages (from-to)1058-1061
Number of pages4
JournalChemistry Letters
Volume48
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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