Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier

Hideki Matsune; Tomoya Ono; Ryoya Yoshida; Tsuyoshi Yamamoto; Masahiro Kishida

doi:10.1246/cl.190353

Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier

Hideki Matsune, Tomoya Ono, Ryoya Yoshida, Tsuyoshi Yamamoto, Masahiro Kishida

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.

Original language	English
Pages (from-to)	1058-1061
Number of pages	4
Journal	Chemistry Letters
Volume	48
Issue number	9
DOIs	https://doi.org/10.1246/cl.190353
Publication status	Published - 2019

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.190353

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abstract = "A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.",

author = "Hideki Matsune and Tomoya Ono and Ryoya Yoshida and Tsuyoshi Yamamoto and Masahiro Kishida",

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AU - Yamamoto, Tsuyoshi

AU - Kishida, Masahiro

N1 - Funding Information: This work was financially supported by JSPS KAKENHI Grant Numbers JP16K06846 and JP18H03856. Publisher Copyright: © 2019 The Chemical Society of Japan Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019

Y1 - 2019

N2 - A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.

AB - A new class of nanoparticle (NP) is fabricated by cross-linking amino-functionalized silsesquioxane units with zinc ions via coordination bonds to create a drug delivery nanocarrier exhibiting rapid drug-release together with self-decomposition in response to glutathione (GSH). Regarding doxorubicin-loaded NPs, characterization of the nanostructures, their responsiveness to GSH and their cellular uptake by HeLa cells are examined.

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Glutathione-responsive nanoparticle consisting of an amino-functionalized silsesquioxane network cross-linked by zinc ions for a promising drug carrier

Abstract

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