Glutathione S-transferase polymorphisms and risk of colorectal adenomas

Hisako Inoue, Chikako Kiyohara, Sachiko Shinomiya, Tomomi Marugame, Emiko Tsuji, Koichi Handa, Hitomi Hayabuchi, Hiroyuki Eguchi, Yoshitaka Fukushima, Suminori Kono

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Glutathione S-transferases (GSTs) are a superfamily of detoxification enzymes that may play an important role in human carcinogenesis. While the genetic polymorphisms GSTM1 and GSTT1 have drawn particular interest in relation to cancer susceptibility, previous studies of colorectal cancer are inconsistent regarding their role. We examined the relation between GSTM1 and GSTT1 genotypes combined and colorectal adenomas, and the interaction with cigarette smoking among 205 cases of colorectal adenomas and 220 controls with normal total colonoscopy in Japanese men. Neither GSTM1 nor GSTT1 was related to colorectal adenomas, nor were the null genotypes of GSTM1 and GSTT1 combined. The lack of an association with GSTM1 and GSTT1 genotypes combined persisted even when the analysis was done separately for proximal and distal colorectal adenomas. A three- to fivefold significant increase in the odds of colorectal adenomas was observed among men with a high exposure to cigarette smoking across the genotype groups, and a statistically significant increasing trend was noted within each genotype group. The present findings do not support the role for GSTM1 and GSTT1 genotypes in the development of colorectal adenomas.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalCancer Letters
Volume163
Issue number2
DOIs
Publication statusPublished - Feb 26 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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