Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer

Jose D. Debes, Akira Yokomizo, Shannon K. McDonnell, Scott J. Hebbring, Gerald B. Christensen, Julie M. Cunningham, Steven J. Jacobsen, Donald J. Tindall, Wanguo Liu, Daniel J. Schaid, Stephen N. Thibodeau

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Abstract

Several reports suggest that the glutathione-S-transferase (GST) family of enzymes is involved in a variety of cancers, due to their carcinogen- detoxification properties. A polymorphism in codon 105 of the pi variant (GSTP1 I105V), which affects the enzymatic activity of the enzyme, has been linked to the incidence of cancers from different organs. However, the published data in prostate cancer (PCa) is controversial. Some studies report an association with the GSTP1 I105V polymorphism and sporadic PCa, whereas other studies report no association. Recently, one study showed a positive correlation between the GSTP1 I105V polymorphism and familial PCa in a Japanese population. In the present study, we assessed the correlation of the GSTP1 I105V polymorphism with familial and sporadic PCa in an American population. We analyzed DNA samples from 438 patients with familial PCa, 499 patients with sporadic PCa, and 510 controls. We found no significant association between the GSTP1 I105V polymorphism and familial or sporadic PCa when compared to the control group [odds ratio (OR) =1.0 (0.74-1.37); P = 0.58]. Moreover, no association was found after stratification for age of diagnosis, Gleason grade, or lymph node involvement [OR =0.84 (0.65-1.09), P = 0.37]. These data indicate that there is no associated risk for sporadic or familial PCa in American families containing the GSTP1 I105V polymorphism.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume155
Issue number1
DOIs
Publication statusPublished - Nov 1 2004

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Transferases
Prostatic Neoplasms
Odds Ratio
Enzymes
Glutathione Transferase
Codon
Carcinogens
Population
Neoplasms
Lymph Nodes
Control Groups
Familial Prostate cancer
DNA
Incidence

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Debes, J. D., Yokomizo, A., McDonnell, S. K., Hebbring, S. J., Christensen, G. B., Cunningham, J. M., ... Thibodeau, S. N. (2004). Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. Cancer Genetics and Cytogenetics, 155(1), 82-86. https://doi.org/10.1016/j.cancergencyto.2004.03.015

Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. / Debes, Jose D.; Yokomizo, Akira; McDonnell, Shannon K.; Hebbring, Scott J.; Christensen, Gerald B.; Cunningham, Julie M.; Jacobsen, Steven J.; Tindall, Donald J.; Liu, Wanguo; Schaid, Daniel J.; Thibodeau, Stephen N.

In: Cancer Genetics and Cytogenetics, Vol. 155, No. 1, 01.11.2004, p. 82-86.

Research output: Contribution to journalArticle

Debes, JD, Yokomizo, A, McDonnell, SK, Hebbring, SJ, Christensen, GB, Cunningham, JM, Jacobsen, SJ, Tindall, DJ, Liu, W, Schaid, DJ & Thibodeau, SN 2004, 'Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer', Cancer Genetics and Cytogenetics, vol. 155, no. 1, pp. 82-86. https://doi.org/10.1016/j.cancergencyto.2004.03.015
Debes JD, Yokomizo A, McDonnell SK, Hebbring SJ, Christensen GB, Cunningham JM et al. Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. Cancer Genetics and Cytogenetics. 2004 Nov 1;155(1):82-86. https://doi.org/10.1016/j.cancergencyto.2004.03.015
Debes, Jose D. ; Yokomizo, Akira ; McDonnell, Shannon K. ; Hebbring, Scott J. ; Christensen, Gerald B. ; Cunningham, Julie M. ; Jacobsen, Steven J. ; Tindall, Donald J. ; Liu, Wanguo ; Schaid, Daniel J. ; Thibodeau, Stephen N. / Gluthatione-S-transferase P1 polymorphism I105V in familial and sporadic prostate cancer. In: Cancer Genetics and Cytogenetics. 2004 ; Vol. 155, No. 1. pp. 82-86.
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