Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle

Yuki Hattori, Daisuke Morita, Nagatoshi Fujiwara, Daiki Mori, Takashi Nakamura, Hideyoshi Harashima, Sho Yamasaki, Masahiko Sugita

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Background:Ahost receptor has not yet been identified for glycerol monomycolate (GroMM), an immunostimulatory lipid of mycobacteria. Results: GroMM recognition occurred in cell transfectants expressing human, but not mouse Mincle. Human Mincle transgenic mice acquired the ability to respond to GroMM. Conclusion: GroMM is a ligand for human Mincle. Significance: The molecular basis underlying the innate immune recognition of GroMM has been elucidated.

    Original languageEnglish
    Pages (from-to)15405-15412
    Number of pages8
    JournalJournal of Biological Chemistry
    Volume289
    Issue number22
    DOIs
    Publication statusPublished - May 30 2014

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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  • Cite this

    Hattori, Y., Morita, D., Fujiwara, N., Mori, D., Nakamura, T., Harashima, H., Yamasaki, S., & Sugita, M. (2014). Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. Journal of Biological Chemistry, 289(22), 15405-15412. https://doi.org/10.1074/jbc.M114.566489