Glycine betaine biosynthesized from glycine provides an osmolyte for cell growth and spore germination during osmotic stress in Myxococcus xanthus

Yoshio Kimura, Shinji Kawasaki, Hinae Yoshimoto, Kaoru Takegawa

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Glycine sarcosine methyltransferase (Gsm) and sarcosine dimethylglycine methyltransferase (Sdm) catalyze glycine betaine synthesis from glycine. Disruption of the M. xanthus gsmA (MXAN 7068) or sdmA (MXAN 3190) gene, encoding Gsm or Sdm homologue proteins, respectively, generated mutants that exhibited a longer lag period of growth and delayed spore germination under osmostress.

Original languageEnglish
Pages (from-to)1467-1470
Number of pages4
JournalJournal of bacteriology
Issue number5
Publication statusPublished - Mar 2010

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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