Glycine response in isolated dorsal cochlear nucleus of C57BL/6J mouse

Seiji Kakehata, Takashi Nakagawa, Tomonori Takasaka, Norio Akaike

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pharmacological properties of glycine (Gly)-induced Cl- current (ICl) in the dorsal cochlear nucleus (DCN) neurons acutely dissociated from C57BL/6J mouse were investigated in the whole-cell configuration of the patch-clamp technique. Gly-induced ICl increased in a sigmoidal manner with higher Gly concentrations. Strychnine blocked the Gly response competitively at low and non-competitively at high concentrations. Both glutamate (Glu) and N-methyl-d-aspartate (NMDA) responses were augmented by adding 10-6 M Gly, at which concentration Gly did not induce any ICl. This facilitation was not affected by strychnine. Our results clearly show the existence of strychnine-sensitive and -insensitive glycine receptors in the DCN neurons.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalBrain Research
Volume574
Issue number1-2
DOIs
Publication statusPublished - Mar 6 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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