Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria

Yuji Sato, Yuichiro Yano, Shouichi Fujimoto, Tsuneo Konta, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe

Research output: Contribution to journalArticle

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Abstract

BackgroundThere is little data on the assessment of prediabetes with proteinuria.MethodsThis is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 Japanese aged <20 years (median 66 years; 39.3 were men; none had pre-existing cardiovascular disease), we examined the association between prediabetes and proteinuria (<1 on dipstick) separately in prediabetes subjects diagnosed with the new hemoglobin A1c (HbA1c) criterion only (PD-A1c), the impaired fasting plasma glucose only (PD-IFG) and fulfilling both criteria (PD-Both).ResultsAccording to the American Diabetes Association's (ADA's) criterion of 5.7-6.4 HbA1c and/or 100-125 mg/dL fasting plasma glucose, 43.8 of the subjects were judged as having prediabetes. Prediabetes subjects were divided into subclasses of PD-A1c (53.7), PD-IFG (21.7) and PD-Both (24.5), respectively. Therefore, 21.7 of prediabetes subjects were missed using the new HbA1c criterion only. Compared with subjects with normal glucose tolerance (as a reference), the odds ratio (OR) [95 confidence interval (95 CI)] for the increased risk of proteinuria (<1) in diabetes itself was 2.191 (2.081-2.307) and in whole prediabetes was 1.093 (1.046-1.142); when prediabetes was subdivided, the OR for proteinuria in PD-IFG was 1.217 (1.140-1.300) and that in PD-Both was 1.249 (1.174-1.329), but that in PD-A1c was not significant, even after adjustment for significant covariates, such as age, sex, body mass index, systolic blood pressure, antihypertensive medication, eGFR, lifestyle and lipid profile.ConclusionsPrediabetes is a significant risk factor for proteinuria compared with completely normal glucose level, and subjects with prediabetes defined using IFG are at significantly higher risk for proteinuria than those defined by HbA1c only.

Original languageEnglish
Pages (from-to)3862-3868
Number of pages7
JournalNephrology Dialysis Transplantation
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 1 2012

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Prediabetic State
Proteinuria
Fasting
Glucose
Hemoglobins
Odds Ratio
Blood Pressure
Preexisting Condition Coverage
Antihypertensive Agents
Life Style
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Cross-Sectional Studies
Databases
Confidence Intervals
Lipids

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Sato, Y., Yano, Y., Fujimoto, S., Konta, T., Iseki, K., Moriyama, T., ... Watanabe, T. (2012). Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. Nephrology Dialysis Transplantation, 27(10), 3862-3868. https://doi.org/10.1093/ndt/gfs324

Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. / Sato, Yuji; Yano, Yuichiro; Fujimoto, Shouichi; Konta, Tsuneo; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Yoshida, Hideaki; Asahi, Koichi; Kurahashi, Issei; Ohashi, Yasuo; Watanabe, Tsuyoshi.

In: Nephrology Dialysis Transplantation, Vol. 27, No. 10, 01.10.2012, p. 3862-3868.

Research output: Contribution to journalArticle

Sato, Y, Yano, Y, Fujimoto, S, Konta, T, Iseki, K, Moriyama, T, Yamagata, K, Tsuruya, K, Yoshida, H, Asahi, K, Kurahashi, I, Ohashi, Y & Watanabe, T 2012, 'Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria', Nephrology Dialysis Transplantation, vol. 27, no. 10, pp. 3862-3868. https://doi.org/10.1093/ndt/gfs324
Sato, Yuji ; Yano, Yuichiro ; Fujimoto, Shouichi ; Konta, Tsuneo ; Iseki, Kunitoshi ; Moriyama, Toshiki ; Yamagata, Kunihiro ; Tsuruya, Kazuhiko ; Yoshida, Hideaki ; Asahi, Koichi ; Kurahashi, Issei ; Ohashi, Yasuo ; Watanabe, Tsuyoshi. / Glycohemoglobin not as predictive as fasting glucose as a measure of prediabetes in predicting proteinuria. In: Nephrology Dialysis Transplantation. 2012 ; Vol. 27, No. 10. pp. 3862-3868.
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abstract = "BackgroundThere is little data on the assessment of prediabetes with proteinuria.MethodsThis is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 Japanese aged <20 years (median 66 years; 39.3 were men; none had pre-existing cardiovascular disease), we examined the association between prediabetes and proteinuria (<1 on dipstick) separately in prediabetes subjects diagnosed with the new hemoglobin A1c (HbA1c) criterion only (PD-A1c), the impaired fasting plasma glucose only (PD-IFG) and fulfilling both criteria (PD-Both).ResultsAccording to the American Diabetes Association's (ADA's) criterion of 5.7-6.4 HbA1c and/or 100-125 mg/dL fasting plasma glucose, 43.8 of the subjects were judged as having prediabetes. Prediabetes subjects were divided into subclasses of PD-A1c (53.7), PD-IFG (21.7) and PD-Both (24.5), respectively. Therefore, 21.7 of prediabetes subjects were missed using the new HbA1c criterion only. Compared with subjects with normal glucose tolerance (as a reference), the odds ratio (OR) [95 confidence interval (95 CI)] for the increased risk of proteinuria (<1) in diabetes itself was 2.191 (2.081-2.307) and in whole prediabetes was 1.093 (1.046-1.142); when prediabetes was subdivided, the OR for proteinuria in PD-IFG was 1.217 (1.140-1.300) and that in PD-Both was 1.249 (1.174-1.329), but that in PD-A1c was not significant, even after adjustment for significant covariates, such as age, sex, body mass index, systolic blood pressure, antihypertensive medication, eGFR, lifestyle and lipid profile.ConclusionsPrediabetes is a significant risk factor for proteinuria compared with completely normal glucose level, and subjects with prediabetes defined using IFG are at significantly higher risk for proteinuria than those defined by HbA1c only.",
author = "Yuji Sato and Yuichiro Yano and Shouichi Fujimoto and Tsuneo Konta and Kunitoshi Iseki and Toshiki Moriyama and Kunihiro Yamagata and Kazuhiko Tsuruya and Hideaki Yoshida and Koichi Asahi and Issei Kurahashi and Yasuo Ohashi and Tsuyoshi Watanabe",
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AU - Sato, Yuji

AU - Yano, Yuichiro

AU - Fujimoto, Shouichi

AU - Konta, Tsuneo

AU - Iseki, Kunitoshi

AU - Moriyama, Toshiki

AU - Yamagata, Kunihiro

AU - Tsuruya, Kazuhiko

AU - Yoshida, Hideaki

AU - Asahi, Koichi

AU - Kurahashi, Issei

AU - Ohashi, Yasuo

AU - Watanabe, Tsuyoshi

PY - 2012/10/1

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N2 - BackgroundThere is little data on the assessment of prediabetes with proteinuria.MethodsThis is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 Japanese aged <20 years (median 66 years; 39.3 were men; none had pre-existing cardiovascular disease), we examined the association between prediabetes and proteinuria (<1 on dipstick) separately in prediabetes subjects diagnosed with the new hemoglobin A1c (HbA1c) criterion only (PD-A1c), the impaired fasting plasma glucose only (PD-IFG) and fulfilling both criteria (PD-Both).ResultsAccording to the American Diabetes Association's (ADA's) criterion of 5.7-6.4 HbA1c and/or 100-125 mg/dL fasting plasma glucose, 43.8 of the subjects were judged as having prediabetes. Prediabetes subjects were divided into subclasses of PD-A1c (53.7), PD-IFG (21.7) and PD-Both (24.5), respectively. Therefore, 21.7 of prediabetes subjects were missed using the new HbA1c criterion only. Compared with subjects with normal glucose tolerance (as a reference), the odds ratio (OR) [95 confidence interval (95 CI)] for the increased risk of proteinuria (<1) in diabetes itself was 2.191 (2.081-2.307) and in whole prediabetes was 1.093 (1.046-1.142); when prediabetes was subdivided, the OR for proteinuria in PD-IFG was 1.217 (1.140-1.300) and that in PD-Both was 1.249 (1.174-1.329), but that in PD-A1c was not significant, even after adjustment for significant covariates, such as age, sex, body mass index, systolic blood pressure, antihypertensive medication, eGFR, lifestyle and lipid profile.ConclusionsPrediabetes is a significant risk factor for proteinuria compared with completely normal glucose level, and subjects with prediabetes defined using IFG are at significantly higher risk for proteinuria than those defined by HbA1c only.

AB - BackgroundThere is little data on the assessment of prediabetes with proteinuria.MethodsThis is a cross-sectional cohort study assessing prediabetes with proteinuria in a large Japanese population. Using a nationwide health checkup database of 228 778 Japanese aged <20 years (median 66 years; 39.3 were men; none had pre-existing cardiovascular disease), we examined the association between prediabetes and proteinuria (<1 on dipstick) separately in prediabetes subjects diagnosed with the new hemoglobin A1c (HbA1c) criterion only (PD-A1c), the impaired fasting plasma glucose only (PD-IFG) and fulfilling both criteria (PD-Both).ResultsAccording to the American Diabetes Association's (ADA's) criterion of 5.7-6.4 HbA1c and/or 100-125 mg/dL fasting plasma glucose, 43.8 of the subjects were judged as having prediabetes. Prediabetes subjects were divided into subclasses of PD-A1c (53.7), PD-IFG (21.7) and PD-Both (24.5), respectively. Therefore, 21.7 of prediabetes subjects were missed using the new HbA1c criterion only. Compared with subjects with normal glucose tolerance (as a reference), the odds ratio (OR) [95 confidence interval (95 CI)] for the increased risk of proteinuria (<1) in diabetes itself was 2.191 (2.081-2.307) and in whole prediabetes was 1.093 (1.046-1.142); when prediabetes was subdivided, the OR for proteinuria in PD-IFG was 1.217 (1.140-1.300) and that in PD-Both was 1.249 (1.174-1.329), but that in PD-A1c was not significant, even after adjustment for significant covariates, such as age, sex, body mass index, systolic blood pressure, antihypertensive medication, eGFR, lifestyle and lipid profile.ConclusionsPrediabetes is a significant risk factor for proteinuria compared with completely normal glucose level, and subjects with prediabetes defined using IFG are at significantly higher risk for proteinuria than those defined by HbA1c only.

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